自乳化给药系统的最新进展:系统专利审查(2011-2020)。

IF 3 4区医学 Q2 PHARMACOLOGY & PHARMACY

Critical Reviews in Therapeutic Drug Carrier Systems Pub Date : 2022-01-01 DOI:10.1615/critrevtherdrugcarriersyst.2021038490

Pedro Sebastián Londoño Ruiz, M. Serafini, I. Alves, Diana Marcela Aragón Novoa

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引用次数: 4

摘要

自乳化给药系统(SEDDS)是一种基于脂质的各向同性混合物，可提高水溶性差药物的生物利用度，减少可能的副作用，为多种疾病提供多种治疗方法。本综述的目的是通过研究最近的专利申请(2011年至2020年)来讨论该药物输送系统的专利现状。我们使用欧洲专利局的Espacenet数据库进行了彻底的筛选，从中选择了37项发明并进行了充分的研究。中国有更多的专利申请，发表的关于SEDDS的文章在数量和技术进步上都超过了提交的发明。然而，本文提出的专利是创新的，解决了传统SEDDS的已知问题，包括储存和配方稳定性，固体配方，表面活性剂的急性胃肠道毒性，以及通过其他给药途径给药。本研究还发现，专利发明人未完全披露SEDDS的释放行为和相关药代动力学，需要进一步研究。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

Recent Progress in Self-Emulsifying Drug Delivery Systems: A Systematic Patent Review (2011-2020).

Self-emulsifying drug delivery systems (SEDDS) are lipid-based isotropic mixtures that enhance the bioavailability of poorly water-soluble drugs and reduce the possible side effects, offering a wide variety of treatments for several pathologies. The aim of this review is to discuss the state of the art of patents for this drug delivery system by studying recent patent applications (2011 to 2020). We performed a thorough screening using the European Patent Office's Espacenet database, from which 37 inventions were selected and fully studied. China had more patent applications, and the articles published about SEDDS exceeds both in number and technological advance the submitted inventions. Nevertheless, the patents presented herein are innovative to address known issues to traditional SEDDS, including storage and formulation stability, solid formulations, acute gastrointestinal toxicity from surfactants, and drug delivery through alternative routes of administration. This study also revealed that release behavior for SEDDS and associated pharmacokinetics were not completely disclosed by the inventors of the patents and that further studies are required.

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来源期刊

Critical Reviews in Therapeutic Drug Carrier Systems 医学-药学

CiteScore

5.50

自引率

18.50%

发文量

审稿时长

>12 weeks

期刊介绍： Therapeutic uses of a variety of drug carrier systems have significant impact on the treatment and potential cure of many chronic diseases, including cancer, diabetes mellitus, psoriasis, parkinsons, Alzheimer, rheumatoid arthritis, HIV infection, infectious diseases, asthma, and drug addiction. Scientific efforts in these areas are multidisciplinary, involving the physical, biological, medical, pharmaceutical, biological materials, and engineering fields. Articles concerning this field appear in a wide variety of journals. With the vast increase in the number of articles and the tendency to fragment science, it becomes increasingly difficult to keep abreast of the literature and to sort out and evaluate the importance and reliability of the data, especially when proprietary considerations are involved. Abstracts and noncritical articles often do not provide a sufficiently reliable basis for proper assessment of a given field without the additional perusal of the original literature. This journal bridges this gap by publishing authoritative, objective, comprehensive multidisciplinary critical review papers with emphasis on formulation and delivery systems. Both invited and contributed articles are subject to peer review.