R. Malla, V. Padmaraju, Krishna Chaitanya Amajala, Gayathri Chalikonda, G. Nagaraju
{"title":"乳腺癌中生物钟与肿瘤微环境的关系。","authors":"R. Malla, V. Padmaraju, Krishna Chaitanya Amajala, Gayathri Chalikonda, G. Nagaraju","doi":"10.1615/critrevoncog.2021040504","DOIUrl":null,"url":null,"abstract":"Breast cancer (BC) is the most common cancer in women. Globally, the incidence of BC surpassed lung cancer for the first time in 2020, and it is highly heterogeneous. The tumor microenvironment (TME) of BC consists of blood vessels, fibroblasts, signaling molecules, immune cells, and extracellular matrix. Numerous studies have provided considerable evidence regarding the association between the circadian rhythm (CR) and human diseases. The CR induces remodeling of the TME cells and their components by disturbing the cellular metabolism, altering gene expression, and aberrantly activating signaling pathways. In this review we present the recent updates on the CR genes and their molecular mechanisms and signaling pathways. In addition, we present the mutations and single nucleotide polymorphisms in the CR genes and the CR pathways in BC biology and the management of the CR in patients with BC. The association between the CR and the TME in BC is also explored.","PeriodicalId":35617,"journal":{"name":"Critical Reviews in Oncogenesis","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"1","resultStr":"{\"title\":\"Association between the Circadian Clock and the Tumor Microenvironment in Breast Cancer.\",\"authors\":\"R. Malla, V. Padmaraju, Krishna Chaitanya Amajala, Gayathri Chalikonda, G. Nagaraju\",\"doi\":\"10.1615/critrevoncog.2021040504\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Breast cancer (BC) is the most common cancer in women. Globally, the incidence of BC surpassed lung cancer for the first time in 2020, and it is highly heterogeneous. The tumor microenvironment (TME) of BC consists of blood vessels, fibroblasts, signaling molecules, immune cells, and extracellular matrix. Numerous studies have provided considerable evidence regarding the association between the circadian rhythm (CR) and human diseases. The CR induces remodeling of the TME cells and their components by disturbing the cellular metabolism, altering gene expression, and aberrantly activating signaling pathways. In this review we present the recent updates on the CR genes and their molecular mechanisms and signaling pathways. In addition, we present the mutations and single nucleotide polymorphisms in the CR genes and the CR pathways in BC biology and the management of the CR in patients with BC. The association between the CR and the TME in BC is also explored.\",\"PeriodicalId\":35617,\"journal\":{\"name\":\"Critical Reviews in Oncogenesis\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2021-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"1\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Critical Reviews in Oncogenesis\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1615/critrevoncog.2021040504\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"Biochemistry, Genetics and Molecular Biology\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Critical Reviews in Oncogenesis","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1615/critrevoncog.2021040504","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"Biochemistry, Genetics and Molecular Biology","Score":null,"Total":0}
Association between the Circadian Clock and the Tumor Microenvironment in Breast Cancer.
Breast cancer (BC) is the most common cancer in women. Globally, the incidence of BC surpassed lung cancer for the first time in 2020, and it is highly heterogeneous. The tumor microenvironment (TME) of BC consists of blood vessels, fibroblasts, signaling molecules, immune cells, and extracellular matrix. Numerous studies have provided considerable evidence regarding the association between the circadian rhythm (CR) and human diseases. The CR induces remodeling of the TME cells and their components by disturbing the cellular metabolism, altering gene expression, and aberrantly activating signaling pathways. In this review we present the recent updates on the CR genes and their molecular mechanisms and signaling pathways. In addition, we present the mutations and single nucleotide polymorphisms in the CR genes and the CR pathways in BC biology and the management of the CR in patients with BC. The association between the CR and the TME in BC is also explored.
期刊介绍:
The journal is dedicated to extensive reviews, minireviews, and special theme issues on topics of current interest in basic and patient-oriented cancer research. The study of systems biology of cancer with its potential for molecular level diagnostics and treatment implies competence across the sciences and an increasing necessity for cancer researchers to understand both the technology and medicine. The journal allows readers to adapt a better understanding of various fields of molecular oncology. We welcome articles on basic biological mechanisms relevant to cancer such as DNA repair, cell cycle, apoptosis, angiogenesis, tumor immunology, etc.