埃塞俄比亚Metema Metema医院收治的内脏利什曼病合并HIV合并感染患者在治疗期间的死亡时间及其决定因素:一项基于医院的横断面研究设计。

IF 2.4 Q3 INFECTIOUS DISEASES
Chekol Alemu, Habitamu Wudu, Getu Dessie, Chalachew Gashu
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引用次数: 0

摘要

背景:内脏利什曼病是由杜氏利什曼原虫香料复合体引起的,这种寄生虫可以传播到内脏,如果不加以治疗,这种疾病是致命的,死亡率接近100%。内脏利什曼原虫HIV(HIV1)合并感染病是利什曼病的一种新的临床形式,在世界流行地区非常严重。它也是埃塞俄比亚低地的主要死亡原因,苏丹边境附近有流行性的Humara和Metema。方法:从2015年1月至2021年1月的患者病历中提取153例合并HIV二次感染的内脏利什曼原虫,并进行基于医院的横断面研究设计以检索相关信息。数据由SPSS输入,并使用STATA版本14和R4.2.1统计软件包进行分析,使用非参数模型、5%显著性水平的半参数Cox比例风险生存模型。结果:在合并HIV感染的内脏利什曼病患者中,女性3.27%,男性96.73%,死亡19例(12.42%),审查134例(87.58%)。Cox比例风险模型结果表明,严重急性营养不良、基线CD4+细胞计数≥100和体重不足对患者的生存时间有显著影响。Cox比例风险模型显示,严重急性营养不良(HR=4.40027,95%CI=2.455061 262.7934,P值=0.007)、基线CD4+细胞计数≥100(HR=0.2714623,95%CI=0.0764089 0.9644395,P值0.044)和体重不足(HR=4.678169,95%CI=1.970097 11.10872,P值P=0.040)显著缩短了生存时间。结论:合并HIV感染的内脏利什曼病患者在治疗的早期出现大量死亡,这意味着内脏利什曼病加速了HIV的复制和疾病进展死亡。研究人员建议人们意识到这些风险因素带来的负担,并了解这些疾病。因此,研究人员建议卫生工作者对这些患者实施初级卫生保健,并仔细考虑一种被忽视的寄生虫病。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Time to death and its determinant factors of visceral leishmaniasis with HIV co-infected patients during treatment period admitted at Metema hospital, Metema, Ethiopia: a hospital-based cross-sectional study design.

Time to death and its determinant factors of visceral leishmaniasis with HIV co-infected patients during treatment period admitted at Metema hospital, Metema, Ethiopia: a hospital-based cross-sectional study design.

Time to death and its determinant factors of visceral leishmaniasis with HIV co-infected patients during treatment period admitted at Metema hospital, Metema, Ethiopia: a hospital-based cross-sectional study design.

Time to death and its determinant factors of visceral leishmaniasis with HIV co-infected patients during treatment period admitted at Metema hospital, Metema, Ethiopia: a hospital-based cross-sectional study design.

Background: Visceral leishmaniasis is caused by the parasites Leishmania donovani spices complex that can spread to internal organs and the disease is fatal with a fatality rate of nearly 100% if left untreated. Visceral Leishmania-HIV (HIV1) coinfection disease is a new clinical form of leishmaniasis very serious disease in the endemic part of the world. It also served as the primary cause of death in the lowlands of Ethiopia with the endemic Humara and Metema that are located near the Sudanese border.

Methods: A total of 153 visceral leishmaniases with HIV co-infection secondary data was taken from the medical chart of patients from January 2015 to January 2021 and a hospital-based cross-sectional study design was carried out to retrieve relevant information. The data entered by SPSS and analysed using STATA version 14 and R4.2.1 statistical software packages using a non-parametric Model, semi-parametric Cox proportional hazard survival models at 5% significance level.

Result: Among the total visceral leishmaniasis with HIV co-infected patients 3.27% were females and 96.73% were males, 19 (12.42%) patients died and 134(87.58%) patients were censored. The Cox proportional hazard model result indicates that severe acute malnutrition, baseline CD4+ cell count ≥100, and underweight significantly contributed to the survival time of a patient. Cox proportional hazard model shows that severe acute malnutrition (HR=4.40027, 95% CI= 2.455061 262.7934, P-value=0.007), baseline CD4+cell count ≥100 (HR=0.2714623, 95% CI= 0.0764089 0.9644395, P-value=0.044), and Underweight (HR=4.678169, 95% CI= 1.970097 11.10872, P-value=0.040) significantly contributed to a shorter survival time.

Conclusion: Visceral leishmaniases with HIV co-infected patients show a large number of deaths occurred in the earlier days of treatment this implies that Visceral leishmaniasis accelerates HIV replication and disease progression death. The researcher suggests that people be aware of the burden posed by those risk factors and knowledgeable about the diseases. So, the researcher recommended that to health workers implement primary health care in those patients and careful consideration of a neglected parasitic disease.

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来源期刊
CiteScore
5.20
自引率
0.00%
发文量
25
审稿时长
17 weeks
期刊介绍: Tropical Diseases, Travel Medicine and Vaccines is an open access journal that considers basic, translational and applied research, as well as reviews and commentary, related to the prevention and management of healthcare and diseases in international travelers. Given the changes in demographic trends of travelers globally, as well as the epidemiological transitions which many countries are experiencing, the journal considers non-infectious problems including chronic disease among target populations of interest as well as infectious diseases.
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