钙在TRPC通道中的转运和传感-对复杂反馈调节的新见解。

IF 4.3 2区生物学 Q2 CELL BIOLOGY

Cell calcium Pub Date : 2023-10-18 DOI:10.1016/j.ceca.2023.102816

Jasmin Baron, Klaus Groschner, Oleksandra Tiapko

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引用次数: 0

摘要

典型TRP（TRPC）通道是一个仍然神秘的具有多峰传感特征的信号分子家族。这些通道使Ca2+能够通过质膜流入，以控制各种细胞功能。基于调节和最近未发现的结构特征，TRPC通道被认为不仅在渗透路径内，而且在额外的感觉位点协调Ca2+和其他二价阳离子。通过冷冻电镜对TRPC结构的分析确定了多个调节性离子结合口袋。通过这篇综述，我们旨在对TRPC通道二价传感的当前概念进行概述和批判性讨论。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Calcium transport and sensing in TRPC channels – New insights into a complex feedback regulation

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Calcium transport and sensing in TRPC channels – New insights into a complex feedback regulation

Canonical TRP (TRPC) channels are a still enigmatic family of signaling molecules with multimodal sensing features. These channels enable Ca²⁺ influx through the plasma membrane to control a diverse range of cellular functions. Based on both regulatory- and recently uncovered structural features, TRPC channels are considered to coordinate Ca²⁺ and other divalent cations not only within the permeation path but also at additional sensory sites. Analysis of TRPC structures by cryo-EM identified multiple regulatory ion binding pockets. With this review, we aim at an overview and a critical discussion of the current concepts of divalent sensing by TRPC channels.

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来源期刊

Cell calcium 生物-细胞生物学

CiteScore

8.70

自引率

5.00%

发文量

115

审稿时长

35 days

期刊介绍： Cell Calcium covers the field of calcium metabolism and signalling in living systems, from aspects including inorganic chemistry, physiology, molecular biology and pathology. Topic themes include: Roles of calcium in regulating cellular events such as apoptosis, necrosis and organelle remodelling Influence of calcium regulation in affecting health and disease outcomes