{"title":"4-环丙基-1,2,5-恶二唑-3-羧酸的连续合成","authors":"艳梅 董","doi":"10.12677/hjmce.2022.113017","DOIUrl":null,"url":null,"abstract":"4-cyclopropyl-1,2,5-oxadiazole-3-carboxylic acid as the bioelectronic row of amide bond has important application value in the field of pharmaceutical chemistry, but the existing conventional synthesis methods use oxidants (potassium permanganate, sodium nitrate), easy to produce explosion risks, difficult to control the reaction, low total yield. In this paper, 3-cyclopropyl isoox-董艳梅","PeriodicalId":64647,"journal":{"name":"药物化学","volume":"1 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Continuous Synthesis of 4-Cyclopropyl-1,2,5-Oxadiazole-3-Carboxylic Acid\",\"authors\":\"艳梅 董\",\"doi\":\"10.12677/hjmce.2022.113017\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"4-cyclopropyl-1,2,5-oxadiazole-3-carboxylic acid as the bioelectronic row of amide bond has important application value in the field of pharmaceutical chemistry, but the existing conventional synthesis methods use oxidants (potassium permanganate, sodium nitrate), easy to produce explosion risks, difficult to control the reaction, low total yield. In this paper, 3-cyclopropyl isoox-董艳梅\",\"PeriodicalId\":64647,\"journal\":{\"name\":\"药物化学\",\"volume\":\"1 1\",\"pages\":\"\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2023-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"药物化学\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.12677/hjmce.2022.113017\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"药物化学","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.12677/hjmce.2022.113017","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Continuous Synthesis of 4-Cyclopropyl-1,2,5-Oxadiazole-3-Carboxylic Acid
4-cyclopropyl-1,2,5-oxadiazole-3-carboxylic acid as the bioelectronic row of amide bond has important application value in the field of pharmaceutical chemistry, but the existing conventional synthesis methods use oxidants (potassium permanganate, sodium nitrate), easy to produce explosion risks, difficult to control the reaction, low total yield. In this paper, 3-cyclopropyl isoox-董艳梅
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