{"title":"儿童咖啡因呼气试验与CYP1A2活性的关系","authors":"E. Webster, J. McIntyre, I. Choonara, T. Preston","doi":"10.1185/146300902322125136","DOIUrl":null,"url":null,"abstract":"The caffeine breath test is a non-invasive method of studying CYP1A2 activity that is suitable for children from the ages of 3 years upwards. It involves the oral administration of a stable isotope and the collection of breath samples for a period of 2 hours. Breath samples are analysed by continuous flow isotope ratio mass spectrometry. It has been used to study both drug interactions and the effect of disease on drug metabolism.","PeriodicalId":87451,"journal":{"name":"Paediatric and perinatal drug therapy","volume":"5 1","pages":"28-33"},"PeriodicalIF":0.0000,"publicationDate":"2002-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"2","resultStr":"{\"title\":\"The Caffeine Breath Test and CYP1A2 Activity in Children\",\"authors\":\"E. Webster, J. McIntyre, I. Choonara, T. Preston\",\"doi\":\"10.1185/146300902322125136\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"The caffeine breath test is a non-invasive method of studying CYP1A2 activity that is suitable for children from the ages of 3 years upwards. It involves the oral administration of a stable isotope and the collection of breath samples for a period of 2 hours. Breath samples are analysed by continuous flow isotope ratio mass spectrometry. It has been used to study both drug interactions and the effect of disease on drug metabolism.\",\"PeriodicalId\":87451,\"journal\":{\"name\":\"Paediatric and perinatal drug therapy\",\"volume\":\"5 1\",\"pages\":\"28-33\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2002-05-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"2\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Paediatric and perinatal drug therapy\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1185/146300902322125136\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Paediatric and perinatal drug therapy","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1185/146300902322125136","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
The Caffeine Breath Test and CYP1A2 Activity in Children
The caffeine breath test is a non-invasive method of studying CYP1A2 activity that is suitable for children from the ages of 3 years upwards. It involves the oral administration of a stable isotope and the collection of breath samples for a period of 2 hours. Breath samples are analysed by continuous flow isotope ratio mass spectrometry. It has been used to study both drug interactions and the effect of disease on drug metabolism.
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