Yeping Song, Yi Zhu, Qinghua Wang, Xin Chen, Yu Chen, Guohao Han, Weipeng Lu* and Yanchuan Guo*,
{"title":"一步法制备高效止血用明胶/聚己内酯纳米纤维Janus膜","authors":"Yeping Song, Yi Zhu, Qinghua Wang, Xin Chen, Yu Chen, Guohao Han, Weipeng Lu* and Yanchuan Guo*, ","doi":"10.1021/acsapm.3c01272","DOIUrl":null,"url":null,"abstract":"<p >One cannot overstate the advantages of an ideal hemostasis material for the emergency rescue of wars and traffic accident victims, and it can significantly mitigate patient distress and minimize threat to life. Nonetheless, it is still a daunting task to obtain a hemostasis material encompassing desirable advantages, including safety, antibacterial activity, high efficiency, sufficient mechanical strength, cost-effectiveness, and so on. In this study, a one-step electrospinning strategy for achieving an efficient hemostatic membrane with a Janus structure is provided. Owing to the synergistic coagulation effect between gelatin nanofibers and zeolite powders (hydrophilic layer), the membrane exhibits excellent coagulation performance in vitro. Simultaneously, the hydrophobic layer’s efficacy in preventing blood permeation further shortens bleeding time and lessens blood loss in vivo. Moreover, the membrane presents commendable flexibility, antibacterial activity, hemocompatibility, and noncytotoxicity, with promise to be used as a safe and efficient hemostatic dressing in clinical applications.</p>","PeriodicalId":7,"journal":{"name":"ACS Applied Polymer Materials","volume":null,"pages":null},"PeriodicalIF":4.4000,"publicationDate":"2023-08-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"One-step Preparation of Antibacterial Gelatin/Polycaprolactone Nanofibrous Janus Membranes for Efficient Hemostasis\",\"authors\":\"Yeping Song, Yi Zhu, Qinghua Wang, Xin Chen, Yu Chen, Guohao Han, Weipeng Lu* and Yanchuan Guo*, \",\"doi\":\"10.1021/acsapm.3c01272\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p >One cannot overstate the advantages of an ideal hemostasis material for the emergency rescue of wars and traffic accident victims, and it can significantly mitigate patient distress and minimize threat to life. Nonetheless, it is still a daunting task to obtain a hemostasis material encompassing desirable advantages, including safety, antibacterial activity, high efficiency, sufficient mechanical strength, cost-effectiveness, and so on. In this study, a one-step electrospinning strategy for achieving an efficient hemostatic membrane with a Janus structure is provided. Owing to the synergistic coagulation effect between gelatin nanofibers and zeolite powders (hydrophilic layer), the membrane exhibits excellent coagulation performance in vitro. Simultaneously, the hydrophobic layer’s efficacy in preventing blood permeation further shortens bleeding time and lessens blood loss in vivo. Moreover, the membrane presents commendable flexibility, antibacterial activity, hemocompatibility, and noncytotoxicity, with promise to be used as a safe and efficient hemostatic dressing in clinical applications.</p>\",\"PeriodicalId\":7,\"journal\":{\"name\":\"ACS Applied Polymer Materials\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":4.4000,\"publicationDate\":\"2023-08-09\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"ACS Applied Polymer Materials\",\"FirstCategoryId\":\"92\",\"ListUrlMain\":\"https://pubs.acs.org/doi/10.1021/acsapm.3c01272\",\"RegionNum\":2,\"RegionCategory\":\"化学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"MATERIALS SCIENCE, MULTIDISCIPLINARY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"ACS Applied Polymer Materials","FirstCategoryId":"92","ListUrlMain":"https://pubs.acs.org/doi/10.1021/acsapm.3c01272","RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"MATERIALS SCIENCE, MULTIDISCIPLINARY","Score":null,"Total":0}
One-step Preparation of Antibacterial Gelatin/Polycaprolactone Nanofibrous Janus Membranes for Efficient Hemostasis
One cannot overstate the advantages of an ideal hemostasis material for the emergency rescue of wars and traffic accident victims, and it can significantly mitigate patient distress and minimize threat to life. Nonetheless, it is still a daunting task to obtain a hemostasis material encompassing desirable advantages, including safety, antibacterial activity, high efficiency, sufficient mechanical strength, cost-effectiveness, and so on. In this study, a one-step electrospinning strategy for achieving an efficient hemostatic membrane with a Janus structure is provided. Owing to the synergistic coagulation effect between gelatin nanofibers and zeolite powders (hydrophilic layer), the membrane exhibits excellent coagulation performance in vitro. Simultaneously, the hydrophobic layer’s efficacy in preventing blood permeation further shortens bleeding time and lessens blood loss in vivo. Moreover, the membrane presents commendable flexibility, antibacterial activity, hemocompatibility, and noncytotoxicity, with promise to be used as a safe and efficient hemostatic dressing in clinical applications.
期刊介绍:
ACS Applied Polymer Materials is an interdisciplinary journal publishing original research covering all aspects of engineering, chemistry, physics, and biology relevant to applications of polymers.
The journal is devoted to reports of new and original experimental and theoretical research of an applied nature that integrates fundamental knowledge in the areas of materials, engineering, physics, bioscience, polymer science and chemistry into important polymer applications. The journal is specifically interested in work that addresses relationships among structure, processing, morphology, chemistry, properties, and function as well as work that provide insights into mechanisms critical to the performance of the polymer for applications.