高雄激素症与肾上腺皮质肿瘤。

2区医学 Q2 Medicine

Frontiers of Hormone Research Pub Date : 2019-01-01 DOI:10.1159/000494905

G. Di Dalmazi

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引用次数: 4

摘要

雄激素分泌肿瘤是肾上腺源性高雄激素症的罕见病因。虽然这些肿瘤在不到2%的患者中被发现，但肾上腺皮质癌的患病率是相关的(2/3的病例)。这些肿瘤与几种雄激素同时升高有关，主要是雄烯二酮、DHEAS和睾酮，在超过一半的患者中，通过免疫测定或质谱测定。尽管最近在肾上腺皮质肿瘤的发病机制方面取得了进展，但迄今为止还没有在这些肿瘤中发现驱动分子事件。本章全面回顾了近20年来关于雄激素分泌肿瘤的所有研究，重点是流行病学、临床表现和激素谱。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Hyperandrogenism and Adrenocortical Tumors.

Androgen-secreting tumors are a rare cause of hyperandrogenism of adrenal origin. Although these tumors are identified in less than 2% of patients, the prevalence of adrenocortical carcinomas is relevant (2/3 of the cases). Those tumors are associated with simultaneous elevation of several androgens, mainly androstenedione, DHEAS, and testosterone, in more than half of the patients, as measured either by immunoassay or mass spectrometry. Despite the recent advances on the pathogenesis of adrenocortical tumors, to date no driver molecular event have been identified in those tumors. This chapter provides a comprehensive review of all studies published in the last 20 years on androgen-secreting tumors, with focus on epidemiology, clinical presentation, and hormonal profile.

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来源期刊

Frontiers of Hormone Research 医学-内分泌学与代谢

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期刊介绍： A series of integrated overviews on cutting-edge topics New sophisticated technologies and methodological approaches in diagnostics and therapeutics have led to significant improvements in identifying and characterizing an increasing number of medical conditions, which is particularly true for all aspects of endocrine and metabolic dysfunctions. Novel insights in endocrine physiology and pathophysiology allow for new perspectives in clinical management and thus lead to the development of molecular, personalized treatments. In view of this, the active interplay between basic scientists and clinicians has become fundamental, both to provide patients with the most appropriate care and to advance future research.