非人类灵长类动物动脉粥样硬化模型中血浆脂蛋白和胆固醇代谢的遗传方面

Monographs in human genetics Pub Date : 1989-01-01 DOI:10.1159/000416894

K. Laber-Laird, L. Rudel

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引用次数: 8

摘要

由于这些原因，猴子是研究遗传和环境对脂蛋白和胆固醇代谢和动脉粥样硬化影响的最实用和最有价值的灵长类动物模型。使用这些灵长类动物作为遗传模型的最大缺点是:1)费用和维护的复杂性，2)漫长的妊娠时间和单胎倾向，这些因素使得猴子的遗传研究很少和困难

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Genetic Aspects of Plasma Lipoprotein and Cholesterol Metabolism in Nonhuman Primate Models of Atherosclerosis

For these reasons, monkeys are the most practical and valuable primate models for studying genetic and environmental influences on lipoprotein and cholesterol metabolism and atherosclerosis. The biggest drawbacks to the use of these primates as genetic models are: 1) the expense and complications of maintenance, and 2) the long gestation time and propensity to single births, factors which make genetic studies in monkeys infrequent and difficult

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Monographs in human genetics

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