自闭症谱系障碍患病率的综合meta分析

Guo Huifen, Maohe Yan, Wang Aizhu, Xiang Zhu
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摘要

背景:关于asd在中国大陆(此后中国)和国外的患病率报道存在矛盾,没有学者对中国和国外的患病率进行比较。需要进一步的研究来阐明患病率的变化,并比较国内外的患病率。目的:比较国内外自闭症的患病率,比较诊断工具、诊断标准等方面的差异。到目前为止,还没有学者比较过中国和国外自闭症的患病率。中国学者几乎没有对中国的全面患病率进行研究,自闭症的患病率也存在矛盾。方法:采用meta分析方法进行研究。首先,根据关键词进行文献检索,并根据筛选标准进行提取。其次,绘制森林图和漏斗图,分析其显著性和异质性。结果:根据诊断标准,asd的总患病率在中国为73.6 / 10000 (95% CI: 14.22-77.96 / 10000 I2 = 80.95%),在国外为98.8 / 10000 (95% CI: 22.35-127.04 / 10000 / 98.14%, I2 = 98.14%)。亚组分析显示,不同性别的自闭症患病率存在显著差异。而且,无论是在中国还是在国外,男性的患病率都远远超过女性。结论:国内外自闭症患病率存在显著差异,诊断标准和诊断工具也存在较大差异。发展中地区与欠发达地区的自闭症患病率存在显著差异,不同性别之间的自闭症患病率也存在差异,但差异不显著。此外,未来患自闭症的人数可能会逐渐增加,了解自闭症的人数也会越来越多,自闭症的老龄化现象也会逐渐增多,自闭症的病因也会越来越复杂。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
A Comprehensive Meta-analysis of the Prevalence of Autism Spectrum Disorders
Background: There are conflicting reports on the prevalence of ASDs in mainland China (China thereafter) and abroad, and no scholars have compared the prevalence in China and abroad. Further studies are needed to clarify the changes in the prevalence rate and compare the prevalence rates at home and abroad. Objective: In order to compare the prevalence of autism at home and abroad, and compare diagnostic tools, diagnostic criteria and other aspects. So far, no scholar has compared the prevalence of autism in China and abroad. Chinese scholars have hardly studied the comprehensive prevalence in China, and the prevalence of autism is conflicting. Methods: I used the Meta-analysis to carry out the research. Firstly, literature was retrieved according to key words and extracted according to screening criteria. Secondly, forest plots and funnel plots were drawn to analyze their significance and heterogeneity. Results: Based on diagnostic criteria the pooled prevalence of ASDs, 73.6 per 10,000 in China (95% CI: 14.22-77.96 per 10,000 I2 = 80.95%), and 98.8 per 10,000 abroad (95% CI: 22.35-127.04 per 10000 per 98.14%, I2 = 98.14%). Subgroup analyses revealed significant difference in the prevalence of ASDs between genders. Moreover, the prevalence of males far exceeds that of females both in China and abroad. Conclusion: There are significant differences in the prevalence of autism at home and abroad, and there are also large differences in diagnostic criteria and diagnostic tools. There are significant differences between developing regions and underdeveloped regions, and there are also differences in the prevalence of autism between different genders, but the differences are not significant. In addition, the number of people suffering from autism may gradually increase in the future, and the number of people who understand autism will become wider and wider, the aging phenomenon of autism will gradually increase, and the causes of autism will become more and more complicated.
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