术前放疗后再切除可改善肢体和胸壁软组织肉瘤非计划切除的局部控制和无进展生存

IF 1.6 Q4 ONCOLOGY
H. Saeed, D. King, C. Johnstone, J. Charlson, D. Hackbarth, J. Neilson, M. Bedi
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引用次数: 21

摘要

背景。软组织肉瘤(STS)的非计划切除(UE)的处理尚未建立。在这项研究中,我们比较了UE与计划切除(PE)的结果,并确定了STS中UE的最佳治疗方法。方法。从2000年到2014年,对所有接受局限性STS治疗的患者进行了回顾。临床结果包括局部无复发生存期(LRFS)、无进展生存期(PFS)和总生存期(OS)使用Kaplan-Meier估计进行评估。进行单因素(UVA)和多因素(MVA)分析以确定预后变量。对于MVA,采用Cox比例风险模型。结果:245例患者纳入分析。14%接受了UE。中位随访时间为2.8年。LR率为8.6%。UE患者的LR率为35%,PE患者为4.2% (p < 0.0001)。UE与PE患者的2年PFS分别为4.2年和9.3年(p = 0.08)。术前放疗(RT) (p = 0.01)和使用任何RT治疗UE (p = 0.003)均可改善PFS。在MVA上,术前RT (p = 0.04)和运动状态(p = 0.01)改善了PFS。结论。与PE相比,UEs导致STS患者LC和PFS降低。术前放疗后再切除可改善STS患者的LC和PFS。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Preoperative Radiation Therapy Followed by Reexcision May Improve Local Control and Progression-Free Survival in Unplanned Excisions of Soft Tissue Sarcomas of the Extremity and Chest-Wall
Background. The management for unplanned excision (UE) of soft tissue sarcomas (STS) has not been established. In this study, we compare outcomes of UE versus planned excision (PE) and determine an optimal treatment for UE in STS. Methods. From 2000 to 2014 a review was performed on all patients treated with localized STS. Clinical outcomes including local recurrence-free survival (LRFS), progression-free survival (PFS), and overall survival (OS) were evaluated using the Kaplan-Meier estimate. Univariate (UVA) and multivariate (MVA) analyses were performed to determine prognostic variables. For MVA, Cox proportional hazards model was used. Results. 245 patients were included in the analysis. 14% underwent UE. Median follow-up was 2.8 years. The LR rate was 8.6%. The LR rate in UE was 35% versus 4.2% in PE patients (p < 0.0001). 2-year PFS in UE versus PE patients was 4.2 years and 9.3 years, respectively (p = 0.08). Preoperative radiation (RT) (p = 0.01) and use of any RT for UE (p = 0.003) led to improved PFS. On MVA, preoperative RT (p = 0.04) and performance status (p = 0.01) led to improved PFS. Conclusions. UEs led to decreased LC and PFS versus PE in patients with STS. The use of preoperative RT followed by reexcision improved LC and PFS in patients who had UE of their STS.
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来源期刊
CiteScore
3.70
自引率
0.00%
发文量
5
审稿时长
20 weeks
期刊介绍: International Journal of Surgical Oncology is a peer-reviewed, Open Access journal that publishes original research articles, review articles, and clinical studies in all areas of surgical oncology.
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