{"title":"可视化细菌在体外产生抗生素耐药性","authors":"Marcia Stone","doi":"10.1128/microbe.11.418.1","DOIUrl":null,"url":null,"abstract":"The development of antibiotic-resistant strains of bacteria depends on a dynamic growth process, involving a program that is far more complex than mere emergence of mutants with higher resistance than their predecessor strains, according to Roy Kishony of Technion-Israel Institute of Technology in Haifa and Harvard Medical School in Boston, Mass., and his collaborators. This conclusion is based on viewing how cells change while growing on “microbial evolution and growth arena (MEGA)” plates, following those cells as they spread along large plates containing antibiotics as well as nutrients. Details appeared 9 September 2016 in Science (doi:10.1126/science.aag0822).","PeriodicalId":87479,"journal":{"name":"Microbe (Washington, D.C.)","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2016-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Visualizing Bacteria as They Develop Antibiotic Resistance in Vitro\",\"authors\":\"Marcia Stone\",\"doi\":\"10.1128/microbe.11.418.1\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"The development of antibiotic-resistant strains of bacteria depends on a dynamic growth process, involving a program that is far more complex than mere emergence of mutants with higher resistance than their predecessor strains, according to Roy Kishony of Technion-Israel Institute of Technology in Haifa and Harvard Medical School in Boston, Mass., and his collaborators. This conclusion is based on viewing how cells change while growing on “microbial evolution and growth arena (MEGA)” plates, following those cells as they spread along large plates containing antibiotics as well as nutrients. Details appeared 9 September 2016 in Science (doi:10.1126/science.aag0822).\",\"PeriodicalId\":87479,\"journal\":{\"name\":\"Microbe (Washington, D.C.)\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2016-12-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Microbe (Washington, D.C.)\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1128/microbe.11.418.1\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Microbe (Washington, D.C.)","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1128/microbe.11.418.1","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
摘要
据海法以色列理工学院(Technion-Israel Institute of Technology)和马萨诸塞州波士顿哈佛医学院(Harvard Medical School)的罗伊·基绍尼(Roy Kishony)说，耐抗生素菌株的发展取决于一个动态的生长过程，涉及的程序远比仅仅出现比其前身菌株具有更高耐药性的突变体要复杂得多。和他的合作者。这一结论是基于观察细胞在“微生物进化和生长舞台(MEGA)”培养皿上生长时的变化，跟踪这些细胞沿着含有抗生素和营养物质的大培养皿扩散。详情刊登在2016年9月9日的《科学》杂志上(doi:10.1126/ Science .aag0822)。
Visualizing Bacteria as They Develop Antibiotic Resistance in Vitro
The development of antibiotic-resistant strains of bacteria depends on a dynamic growth process, involving a program that is far more complex than mere emergence of mutants with higher resistance than their predecessor strains, according to Roy Kishony of Technion-Israel Institute of Technology in Haifa and Harvard Medical School in Boston, Mass., and his collaborators. This conclusion is based on viewing how cells change while growing on “microbial evolution and growth arena (MEGA)” plates, following those cells as they spread along large plates containing antibiotics as well as nutrients. Details appeared 9 September 2016 in Science (doi:10.1126/science.aag0822).
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
