{"title":"微生物作为内含子的避风港:这些微生物,内含子样多肽是自剪接元件,在翻译后从宿主蛋白中移除自己","authors":"Cathleen M. Green, M. Belfort","doi":"10.1128/MICROBE.11.388.1","DOIUrl":null,"url":null,"abstract":"Inteins are polypeptide escape artists, with an extraordinary ability to excise themselves from fully folded proteins without leaving a trace. Inteins are best described as protein introns, self-splicing elements that remove themselves posttranslationally from their host proteins. They occur in all three domains of life—archaea, bacteria, and single-celled eukaryotes (Fig. 1A). Even so, inteins are rarely discussed among microbiologists, but this relative silence is about to be broken.","PeriodicalId":87479,"journal":{"name":"Microbe (Washington, D.C.)","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2016-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Microbes as Intein Havens: These microbial, intron-like polypeptides are self-splicing elements that remove themselves posttranslationally from their host proteins\",\"authors\":\"Cathleen M. Green, M. Belfort\",\"doi\":\"10.1128/MICROBE.11.388.1\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Inteins are polypeptide escape artists, with an extraordinary ability to excise themselves from fully folded proteins without leaving a trace. Inteins are best described as protein introns, self-splicing elements that remove themselves posttranslationally from their host proteins. They occur in all three domains of life—archaea, bacteria, and single-celled eukaryotes (Fig. 1A). Even so, inteins are rarely discussed among microbiologists, but this relative silence is about to be broken.\",\"PeriodicalId\":87479,\"journal\":{\"name\":\"Microbe (Washington, D.C.)\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2016-09-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Microbe (Washington, D.C.)\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1128/MICROBE.11.388.1\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Microbe (Washington, D.C.)","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1128/MICROBE.11.388.1","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Microbes as Intein Havens: These microbial, intron-like polypeptides are self-splicing elements that remove themselves posttranslationally from their host proteins
Inteins are polypeptide escape artists, with an extraordinary ability to excise themselves from fully folded proteins without leaving a trace. Inteins are best described as protein introns, self-splicing elements that remove themselves posttranslationally from their host proteins. They occur in all three domains of life—archaea, bacteria, and single-celled eukaryotes (Fig. 1A). Even so, inteins are rarely discussed among microbiologists, but this relative silence is about to be broken.