{"title":"男性和女性对病毒和疫苗的免疫反应不同:性激素会引发女性和男性对传染性病原体和疫苗的不同反应","authors":"Shannon Weiman","doi":"10.1128/MICROBE.11.383.1","DOIUrl":null,"url":null,"abstract":"Human sex differences extend beyond anatomy to encompass important immune system functions, predisposing men and women to respond differently to infectious diseases. For instance, estrogens tend to promote stronger inflammatory, cellular, and humoral immune responses in women than men. While robust immune responses to pathogens can benefit the host, overexuberant inflammatory responses can damage host tissues—predisposing women more than men to develop immunopathologies, comorbidities, autoimmune disorders, and adverse reactions to vaccines, among other deleterious effects.","PeriodicalId":87479,"journal":{"name":"Microbe (Washington, D.C.)","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2016-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1128/MICROBE.11.383.1","citationCount":"2","resultStr":"{\"title\":\"Immune Responses to Viruses and Vaccines Differ Between Men and Women: Sex hormones can trigger differential responses between females and males to infectious agents and vaccines\",\"authors\":\"Shannon Weiman\",\"doi\":\"10.1128/MICROBE.11.383.1\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Human sex differences extend beyond anatomy to encompass important immune system functions, predisposing men and women to respond differently to infectious diseases. For instance, estrogens tend to promote stronger inflammatory, cellular, and humoral immune responses in women than men. While robust immune responses to pathogens can benefit the host, overexuberant inflammatory responses can damage host tissues—predisposing women more than men to develop immunopathologies, comorbidities, autoimmune disorders, and adverse reactions to vaccines, among other deleterious effects.\",\"PeriodicalId\":87479,\"journal\":{\"name\":\"Microbe (Washington, D.C.)\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2016-09-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1128/MICROBE.11.383.1\",\"citationCount\":\"2\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Microbe (Washington, D.C.)\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1128/MICROBE.11.383.1\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Microbe (Washington, D.C.)","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1128/MICROBE.11.383.1","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Immune Responses to Viruses and Vaccines Differ Between Men and Women: Sex hormones can trigger differential responses between females and males to infectious agents and vaccines
Human sex differences extend beyond anatomy to encompass important immune system functions, predisposing men and women to respond differently to infectious diseases. For instance, estrogens tend to promote stronger inflammatory, cellular, and humoral immune responses in women than men. While robust immune responses to pathogens can benefit the host, overexuberant inflammatory responses can damage host tissues—predisposing women more than men to develop immunopathologies, comorbidities, autoimmune disorders, and adverse reactions to vaccines, among other deleterious effects.