用于代谢远程监测的全植入式多面板设备的体内验证。

IF 3.8 2区医学 Q2 ENGINEERING, BIOMEDICAL

IEEE Transactions on Biomedical Circuits and Systems Pub Date : 2016-10-01 DOI:10.1109/TBCAS.2016.2584239

C. Baj-Rossi, A. Cavallini, Enver G. Kilinc, Francesca Stradolini, T. Rezzonico Jost, M. Proietti, G. De Micheli, F. Grassi, C. Dehollain, S. Carrara

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引用次数: 3

摘要

本文介绍了一种用于内源性和外源性分析物远程监测的全植入式多面板设备的体内测试。为了探讨其生物相容性问题，设计、实现了三种不同的盖层，并在小鼠体内进行了30天的试验。在装置外植后，在植入部位测量ATP和中性粒细胞浓度，以评估装置的生物相容性水平。最后，该装置的完整工作原型被植入老鼠体内并进行测试。植入的装置被用来检测葡萄糖和扑热息痛生理浓度的变化。这些分析物的数据趋势已被成功地获取并传送到外部基站。葡萄糖和扑热息痛(也被称为对乙酰氨基酚)在这项研究中被提出作为模型分子应用于个性化和转化医学。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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In-Vivo Validation of Fully Implantable Multi-Panel Devices for Remote Monitoring of Metabolism.

This paper presents the in-vivo tests on a Fully Implantable Multi-Panel Devices for Remote Monitoring of endogenous and exogenous analytes. To investigate issues on biocompatibility, three different covers have been designed, realized and tested in mice for 30 days. ATP and neutrophil concentrations have been measured, at the implant site after the device was explanted, to assess the level of biocompatibility of the device. Finally, fully working prototypes of the device were implanted in mice and tested. The implanted devices were used to detect variations in the physiological concentrations of glucose and paracetamol. Data trends on these analytes have been successfully acquired and transmitted to the external base station. Glucose and paracetamol (also named acetaminophen) have been proposed in this research as model molecules for applications to personalized and translational medicine.

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来源期刊

IEEE Transactions on Biomedical Circuits and Systems 工程技术-工程：电子与电气

CiteScore

10.00

自引率

13.70%

发文量

174

审稿时长

3 months

期刊介绍： The IEEE Transactions on Biomedical Circuits and Systems addresses areas at the crossroads of Circuits and Systems and Life Sciences. The main emphasis is on microelectronic issues in a wide range of applications found in life sciences, physical sciences and engineering. The primary goal of the journal is to bridge the unique scientific and technical activities of the Circuits and Systems Society to a wide variety of related areas such as: • Bioelectronics • Implantable and wearable electronics like cochlear and retinal prosthesis, motor control, etc. • Biotechnology sensor circuits, integrated systems, and networks • Micropower imaging technology • BioMEMS • Lab-on-chip Bio-nanotechnology • Organic Semiconductors • Biomedical Engineering • Genomics and Proteomics • Neuromorphic Engineering • Smart sensors • Low power micro- and nanoelectronics • Mixed-mode system-on-chip • Wireless technology • Gene circuits and molecular circuits • System biology • Brain science and engineering: such as neuro-informatics, neural prosthesis, cognitive engineering, brain computer interface • Healthcare: information technology for biomedical, epidemiology, and other related life science applications. General, theoretical, and application-oriented papers in the abovementioned technical areas with a Circuits and Systems perspective are encouraged to publish in TBioCAS. Of special interest are biomedical-oriented papers with a Circuits and Systems angle.