炎症后色素沉着的病理生理研究综述

IF 3.9 3区医学 Q2 CELL BIOLOGY

Pigment Cell & Melanoma Research Pub Date : 2022-03-20 DOI:10.1111/pcmr.13038

Jalal Maghfour, Jadesola Olayinka, Iltefat H. Hamzavi, Tasneem F. Mohammad

{"title":"炎症后色素沉着的病理生理研究综述","authors":"Jalal Maghfour, Jadesola Olayinka, Iltefat H. Hamzavi, Tasneem F. Mohammad","doi":"10.1111/pcmr.13038","DOIUrl":null,"url":null,"abstract":"<p>Post-inflammatory hyperpigmentation (PIH) is one of the most common disorders of acquired hyperpigmentation. It often develops following cutaneous inflammation and is triggered by various stimuli, from inflammatory and autoimmune conditions to iatrogenic causes and mechanical injuries. While it is well established that an increase in melanin production and distribution within the epidermis and dermis is a hallmark feature of this condition, the exact mechanisms underlying PIH are not completely understood. This article aims to review the current evidence on the pathophysiology of PIH as the cellular and molecular mechanism of PIH represents a promising avenue for the development of novel, targeted therapies.</p>","PeriodicalId":219,"journal":{"name":"Pigment Cell & Melanoma Research","volume":"35 3","pages":"320-327"},"PeriodicalIF":3.9000,"publicationDate":"2022-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/pcmr.13038","citationCount":"7","resultStr":"{\"title\":\"A Focused review on the pathophysiology of post-inflammatory hyperpigmentation\",\"authors\":\"Jalal Maghfour, Jadesola Olayinka, Iltefat H. Hamzavi, Tasneem F. Mohammad\",\"doi\":\"10.1111/pcmr.13038\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p>Post-inflammatory hyperpigmentation (PIH) is one of the most common disorders of acquired hyperpigmentation. It often develops following cutaneous inflammation and is triggered by various stimuli, from inflammatory and autoimmune conditions to iatrogenic causes and mechanical injuries. While it is well established that an increase in melanin production and distribution within the epidermis and dermis is a hallmark feature of this condition, the exact mechanisms underlying PIH are not completely understood. This article aims to review the current evidence on the pathophysiology of PIH as the cellular and molecular mechanism of PIH represents a promising avenue for the development of novel, targeted therapies.</p>\",\"PeriodicalId\":219,\"journal\":{\"name\":\"Pigment Cell & Melanoma Research\",\"volume\":\"35 3\",\"pages\":\"320-327\"},\"PeriodicalIF\":3.9000,\"publicationDate\":\"2022-03-20\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://onlinelibrary.wiley.com/doi/epdf/10.1111/pcmr.13038\",\"citationCount\":\"7\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Pigment Cell & Melanoma Research\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://onlinelibrary.wiley.com/doi/10.1111/pcmr.13038\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"CELL BIOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Pigment Cell & Melanoma Research","FirstCategoryId":"3","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1111/pcmr.13038","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"CELL BIOLOGY","Score":null,"Total":0}

引用次数: 7

摘要

炎症后色素沉着症(PIH)是获得性色素沉着症最常见的疾病之一。它通常发生在皮肤炎症之后，并由各种刺激触发，从炎症和自身免疫性疾病到医源性原因和机械损伤。虽然已经确定黑色素在表皮和真皮层内产生和分布的增加是这种疾病的标志特征，但PIH的确切机制尚不完全清楚。本文旨在回顾目前关于PIH病理生理的证据，因为PIH的细胞和分子机制代表了开发新型靶向治疗的有希望的途径。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

A Focused review on the pathophysiology of post-inflammatory hyperpigmentation

Post-inflammatory hyperpigmentation (PIH) is one of the most common disorders of acquired hyperpigmentation. It often develops following cutaneous inflammation and is triggered by various stimuli, from inflammatory and autoimmune conditions to iatrogenic causes and mechanical injuries. While it is well established that an increase in melanin production and distribution within the epidermis and dermis is a hallmark feature of this condition, the exact mechanisms underlying PIH are not completely understood. This article aims to review the current evidence on the pathophysiology of PIH as the cellular and molecular mechanism of PIH represents a promising avenue for the development of novel, targeted therapies.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

Pigment Cell & Melanoma Research 医学-皮肤病学

CiteScore

8.90

自引率

2.30%

发文量

审稿时长

6-12 weeks

期刊介绍： Pigment Cell & Melanoma Researchpublishes manuscripts on all aspects of pigment cells including development, cell and molecular biology, genetics, diseases of pigment cells including melanoma. Papers that provide insights into the causes and progression of melanoma including the process of metastasis and invasion, proliferation, senescence, apoptosis or gene regulation are especially welcome, as are papers that use the melanocyte system to answer questions of general biological relevance. Papers that are purely descriptive or make only minor advances to our knowledge of pigment cells or melanoma in particular are not suitable for this journal. Keywords Pigment Cell & Melanoma Research, cell biology, melatonin, biochemistry, chemistry, comparative biology, dermatology, developmental biology, genetics, hormones, intracellular signalling, melanoma, molecular biology, ocular and extracutaneous melanin, pharmacology, photobiology, physics, pigmentary disorders