妊娠期和生长期葡萄糖调控遗传学(Gen3G)队列中孕妇胰岛素敏感性与儿童期中枢性肥胖的关系

IF 2.7 3区医学 Q1 PEDIATRICS

Pediatric Obesity Pub Date : 2022-10-11 DOI:10.1111/ijpo.12982

Nidhi Ghildayal, Catherine Allard, Kasandra Blais, Myriam Doyon, Melina Arguin, Luigi Bouchard, Patrice Perron, Marie-France Hivert

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引用次数: 0

摘要

儿童肥胖与产前暴露于母体高血糖有关，但我们缺乏对母体胰岛素生理成分的了解，有助于这种关联。目的评价孕妇妊娠期胰岛素敏感性与儿童期肥胖指标之间的关系。方法在422对母子中，我们测试了怀孕~26周时母亲胰岛素敏感性测量与儿童肥胖测量之间的关系，包括双能x线吸收测量身体成分和5岁时的人体测量(体重指数和腰围)。我们使用线性回归分析来调整母亲年龄、种族、妊娠、妊娠早期体重指数、儿童性别和儿童中期年龄。结果孕早期产妇平均年龄28.6±4.3岁，中位体重指数24.1 kg/m2。基于人体测量和双能x线吸收测量总脂肪和躯干脂肪百分比的单变量关联，较低的母亲胰岛素敏感性指数与较高的儿童肥胖相关(r = - 0.122至- 0.159)。较低的母亲胰岛素敏感性与较高的双能x线吸收测量躯干脂肪%特异性相关(n = 359 for Matsuda;β =−0.034±0.013;P = 0.01)，校正协变量，包括母亲体重指数。结论妊娠期孕妇胰岛素敏感性可能增加子代中枢性肥胖的风险。

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Associations of maternal insulin sensitivity during pregnancy with childhood central adiposity in the Genetics of Glucose regulation in Gestation and Growth (Gen3G) cohort

Background

Childhood obesity has been associated with prenatal exposure to maternal hyperglycaemia, but we lack understanding about maternal insulin physiologic components that contribute to this association.

Objectives

Evaluate the association between maternal insulin sensitivity during pregnancy and adiposity measures in childhood.

Methods

In 422 mother–child pairs, we tested associations between maternal insulin sensitivity measures at ~26 weeks of pregnancy and child adiposity measures, including dual-energy X-ray absorptiometry body composition and anthropometry (body mass index and waist circumference) at ~5 years. We used linear regression analyses to adjust for maternal age, ethnicity, gravidity, first-trimester body mass index, and child sex and age at mid-childhood.

Results

In early pregnancy, maternal mean age was 28.6 ± 4.3 years and median body mass index was 24.1 kg/m². Lower maternal insulin sensitivity indices were correlated with greater child adiposity based on anthropometry measures and on dual-energy X-ray absorptiometry total and trunk % fat in univariate associations (r = −0.122 to −0.159). Lower maternal insulin sensitivity was specifically associated with higher dual-energy X-ray absorptiometry trunk % fat (n = 359 for Matsuda; β = −0.034 ± 0.013; p = 0.01) after adjustment for covariates, including maternal body mass index.

Conclusions

Maternal insulin sensitivity during pregnancy may contribute to increased risk for higher offspring central adiposity in middle childhood.

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来源期刊

Pediatric Obesity PEDIATRICS-

CiteScore

7.30

自引率

5.30%

发文量

117

审稿时长

6-12 weeks

期刊介绍： Pediatric Obesity is a peer-reviewed, monthly journal devoted to research into obesity during childhood and adolescence. The topic is currently at the centre of intense interest in the scientific community, and is of increasing concern to health policy-makers and the public at large. Pediatric Obesity has established itself as the leading journal for high quality papers in this field, including, but not limited to, the following: Genetic, molecular, biochemical and physiological aspects of obesity – basic, applied and clinical studies relating to mechanisms of the development of obesity throughout the life course and the consequent effects of obesity on health outcomes Metabolic consequences of child and adolescent obesity Epidemiological and population-based studies of child and adolescent overweight and obesity Measurement and diagnostic issues in assessing child and adolescent adiposity, physical activity and nutrition Clinical management of children and adolescents with obesity including studies of treatment and prevention Co-morbidities linked to child and adolescent obesity – mechanisms, assessment, and treatment Life-cycle factors eg familial, intrauterine and developmental aspects of child and adolescent obesity Nutrition security and the "double burden" of obesity and malnutrition Health promotion strategies around the issues of obesity, nutrition and physical activity in children and adolescents Community and public health measures to prevent overweight and obesity in children and adolescents.