与晚期年龄相关性黄斑变性进展相关的预后因素的系统评价:Pinnacle研究报告2。

IF 5.1 2区 医学 Q1 OPHTHALMOLOGY
Ahmed M. Hagag , Rebecca Kaye , Vy Hoang , Sophie Riedl , Philipp Anders , Beth Stuart , Ghislaine Traber , Christian Appenzeller-Herzog , Ursula Schmidt-Erfurth , Hrvoje Bogunovic , Hendrik P. Scholl , Toby Prevost , Lars Fritsche , Daniel Rueckert , Sobha Sivaprasad , Andrew J. Lotery
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引用次数: 0

摘要

需要准确确定决定中晚期年龄相关性黄斑变性(AMD)进展的预后因素。目前,临床医生无法提供疾病进展的个体化预后。此外,用快速进展者丰富临床试验可能有助于提供旨在延迟或预防晚期AMD进展的较短干预试验。因此,我们进行了一项系统综述,以概述和评估报告中晚期AMD进展的预后因素的准确性。最初计划进行荟萃分析。AMD和疾病进展的同义词用于搜索Medline和EMBASE,以查找1991年至2021年间发表的研究AMD进展的文章。最初的搜索结果包括3229篇文章。采用预先确定的资格标准,由两名独立和重复工作的评审员系统地筛选论文。质量评估和数据提取由一个审查小组进行。只有6个研究符合资格标准。基于这些文章,中晚期AMD进展的探索性预后因素包括表型特征(如核果的位置和大小)、年龄、吸烟状况、眼部和全身合并症、种族和基因型。总体而言,研究的异质性排除了森林图和荟萃分析的报告。最常见的预后因素是与进展为新生血管性AMD相关的基线核糖核酸酶体积/大小,以及与进展为地理性萎缩相关的外视网膜变薄。总之,纳入研究的方法论质量差,需要对我们的研究结果进行谨慎的解释。有必要进行严格的研究,以便在未来提供有力的证据。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Systematic review of prognostic factors associated with progression to late age-related macular degeneration: Pinnacle study report 2

There is a need to identify accurately prognostic factors that determine the progression of intermediate to late-stage age-related macular degeneration (AMD). Currently, clinicians cannot provide individualised prognoses of disease progression. Moreover, enriching clinical trials with rapid progressors may facilitate delivery of shorter intervention trials aimed at delaying or preventing progression to late AMD. Thus, we performed a systematic review to outline and assess the accuracy of reporting prognostic factors for the progression of intermediate to late AMD. A meta-analysis was originally planned. Synonyms of AMD and disease progression were used to search Medline and EMBASE for articles investigating AMD progression published between 1991 and 2021. Initial search results included 3229 articles. Predetermined eligibility criteria were employed to systematically screen papers by two reviewers working independently and in duplicate. Quality appraisal and data extraction were performed by a team of reviewers. Only 6 studies met the eligibility criteria. Based on these articles, exploratory prognostic factors for progression of intermediate to late AMD included phenotypic features (e.g. location and size of drusen), age, smoking status, ocular and systemic co-morbidities, race, and genotype. Overall, study heterogeneity precluded reporting by forest plots and meta-analysis. The most commonly reported prognostic factors were baseline drusen volume/size, which was associated with progression to neovascular AMD, and outer retinal thinning linked to progression to geographic atrophy. In conclusion, poor methodological quality of included studies warrants cautious interpretation of our findings. Rigorous studies are warranted to provide robust evidence in the future.

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来源期刊
Survey of ophthalmology
Survey of ophthalmology 医学-眼科学
CiteScore
10.30
自引率
2.00%
发文量
138
审稿时长
14.8 weeks
期刊介绍: Survey of Ophthalmology is a clinically oriented review journal designed to keep ophthalmologists up to date. Comprehensive major review articles, written by experts and stringently refereed, integrate the literature on subjects selected for their clinical importance. Survey also includes feature articles, section reviews, book reviews, and abstracts.
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