孕妇尿酸水平与妊娠期糖尿病风险:一项包括105,380名参与者的队列研究的系统回顾和剂量反应荟萃分析

IF 3.2 3区医学

Journal of Diabetes Investigation Pub Date : 2023-05-03 DOI:10.1111/jdi.14022

Ali Nikparast, Jamal Rahmani, Reza Bagheri, Saba Mohammadpour, Mehdi Shadnoosh, Alexei Wong, Matin Ghanavati

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引用次数: 1

摘要

虽然尿酸水平与不良妊娠结局之间的关系已被研究，但尿酸水平升高对妊娠期糖尿病(GDM)风险的影响尚未确定。因此，本系统综述和荟萃分析旨在探讨妊娠期间尿酸水平与GDM风险之间的关系。材料与方法检索PubMed/Medline、Scopus和Web of Science数据库，检索截止到2022年4月的相关观察性研究。随机效应模型用于估计合并优势比(OR)和95%置信区间(95% CI)。为了评估纳入研究的异质性，使用I2指数。结果在最初的262项研究中，包括105380名参与者的23项研究符合条件。合并分析显示，较高的尿酸水平显著影响GDM的风险(OR 2.58, 95% CI 1.89-3.52, I2 = 90.8%， P < 0.001)。基于妊娠周的亚组分析显示，妊娠20周前较高的尿酸水平与GDM的风险显著相关(OR 3.26, 95% CI 2.26-4.71, I2 = 89.3%， P < 0.001)。meta回归分析发现，尿酸水平和GDM的几率与受试者的年龄显著相关，且在年龄较小的孕妇中更为显著。结论:本研究显示尿酸水平与GDM风险呈正相关。此外，我们的研究结果表明，在妊娠20周之前测量尿酸水平可以潜在地预测GDM，特别是在年轻女性中。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Maternal uric acid levels and risk of gestational diabetes mellitus: A systematic review and dose–response meta-analysis of cohort studies including 105,380 participants

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Maternal uric acid levels and risk of gestational diabetes mellitus: A systematic review and dose–response meta-analysis of cohort studies including 105,380 participants

Aims/Introduction

Although the association between uric acid levels and adverse pregnancy outcomes has been investigated, the effects of higher uric acid levels on the risk of gestational diabetes mellitus (GDM) have yet to be established. Therefore, this systematic review and meta-analysis aimed to investigate the relationship between uric acid levels during pregnancy and the risk of GDM.

Materials and Methods

PubMed/Medline, Scopus and Web of Science databases were searched up to April 2022 for relevant observational studies. A random effects model was used to estimate pooled odds ratios (OR) and 95% confidence intervals (95% CI). To assess the heterogeneity of included studies, the I² index was used.

Results

Among the initial 262 studies that were recognized from the databases search, 23 studies including 105,380 participants were eligible. Pooled analysis showed that higher uric acid levels significantly affected the risk of GDM (OR 2.58, 95% CI 1.89–3.52, I² = 90.8%, P < 0.001). Subgroup analyses based on the gestational week showed that higher uric acid levels before the 20th week of gestation were significantly associated with the risk of GDM (OR 3.26, 95% CI 2.26–4.71, I² = 89.3%, P < 0.001). Based on the meta-regression analysis, uric acid levels and odds of GDM were significantly correlated with the participants' age, and it was more significant in younger pregnant women.

Conclusions

This study showed a positive association between uric acid levels and the risk of GDM. Also, our results indicate that measuring uric acid levels before 20 weeks of gestation can potentially predict GDM, especially in younger women.

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来源期刊

Journal of Diabetes Investigation Medicine-Internal Medicine

自引率

9.40%

发文量

218

期刊介绍： Journal of Diabetes Investigation is your core diabetes journal from Asia; the official journal of the Asian Association for the Study of Diabetes (AASD). The journal publishes original research, country reports, commentaries, reviews, mini-reviews, case reports, letters, as well as editorials and news. Embracing clinical and experimental research in diabetes and related areas, the Journal of Diabetes Investigation includes aspects of prevention, treatment, as well as molecular aspects and pathophysiology. Translational research focused on the exchange of ideas between clinicians and researchers is also welcome. Journal of Diabetes Investigation is indexed by Science Citation Index Expanded (SCIE).