具有疾病敏感单倍型的非亲属供体脐带血移植后的1型糖尿病

IF 3.2 3区医学

Journal of Diabetes Investigation Pub Date : 2022-11-02 DOI:10.1111/jdi.13939

Kensuke Matsumoto, Taisuke Matsuyama, Ritsu Sumiyoshi, Matsuo Takuji, Tadashi Yamamoto, Ryosuke Shirasaki, Haruko Tashiro

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引用次数: 1

摘要

同种异体造血干细胞移植(allogene hematopoietic stem cell transplantation, alloo - hsct)是治疗造血肿瘤的一种有效方法，但它经常引起各种自身免疫性疾病样疾病。相比之下，与同种异体造血干细胞移植相关的1型糖尿病极为罕见。在此，我们报告了一例接受脐带血移植(CBT)治疗急性髓系白血病的患者发生同种异体造血干细胞相关的1型糖尿病。患者的人白细胞抗原在移植后被替换为供体类型。供体具有对疾病敏感的单倍型。据我们所知，这是CBT后第一例1型糖尿病的报道。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Type 1 diabetes mellitus after cord blood transplantation from an unrelated donor with a disease-sensitive haplotype

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Type 1 diabetes mellitus after cord blood transplantation from an unrelated donor with a disease-sensitive haplotype

Allogeneic hematopoietic stem cell transplantation (allo-HSCT), a curative treatment for hematopoietic neoplasms, often causes various autoimmune disease-like conditions. In contrast, allo-HSCT-related type 1 diabetes mellitus is extremely rare. Herein, we report a case of allo-HSCT-related type 1 diabetes mellitus in a patient who had undergone cord blood transplantation (CBT) as a treatment for acute myeloid leukemia. The patient's human leukocyte antigen was replaced with the donor type after transplantation. The donor had a disease-sensitive haplotype. To the best of our knowledge, this is the first reported case of type 1 diabetes mellitus following CBT.

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来源期刊

Journal of Diabetes Investigation Medicine-Internal Medicine

自引率

9.40%

发文量

218

期刊介绍： Journal of Diabetes Investigation is your core diabetes journal from Asia; the official journal of the Asian Association for the Study of Diabetes (AASD). The journal publishes original research, country reports, commentaries, reviews, mini-reviews, case reports, letters, as well as editorials and news. Embracing clinical and experimental research in diabetes and related areas, the Journal of Diabetes Investigation includes aspects of prevention, treatment, as well as molecular aspects and pathophysiology. Translational research focused on the exchange of ideas between clinicians and researchers is also welcome. Journal of Diabetes Investigation is indexed by Science Citation Index Expanded (SCIE).