Ruilong Ran, Yan Peng, Lang Xiao, Yanlai Wang, Tonghua Zhang, Zhongwen Liu, Zhi Li
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Fabrication of antimicrobial poly(lactic-co-glycolic acid)/silk fibroin/aloe anthraquinone fibrous membranes for potential application of wound healing
Antibacterial wound dressings can kill bacteria around the wound and then accelerate the wound healing. To fabricate an antibacterial membrane for potential application of wound healing, poly(lactic-co-glycolic acid) (PLGA), silk fibroin (SF), and natural antimicrobial agent aloe anthraquinone (AA) were blended for electrospinning. The electrospun PLGA/SF/AA fibrous membrane consists of smooth and uniform fibers with an average diameter of 583 ± 112 nm. The stress of the PLGA/SF/AA fibrous membrane is 3.88 ± 0.34 MPa, which can ensure its application in skin wound healing. Owing to the good hydrophilicity of blended SF, PLGA/SF/AA fibrous membrane can release 47% of AA at 48 h and 62% of AA in 15 days. PLGA/SF/AA membrane also exhibits good antimicrobial properties and cell compatibility. These results indicate that the fabricated PLGA/SF/AA fibrous membrane in this study has a good application potential for wound healing.
期刊介绍：
The Journal of Applied Polymer Science is the largest peer-reviewed publication in polymers, #3 by total citations, and features results with real-world impact on membranes, polysaccharides, and much more.
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