血管紧张素受体-奈普利素抑制剂在临床糖尿病管理中的影响:潜在的益处和缺陷

IF 3.2 3区医学

Journal of Diabetes Investigation Pub Date : 2023-06-25 DOI:10.1111/jdi.14044

Tomoko Kato, Takaaki Murakami, Daisuke Yabe, Norio Harada

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引用次数: 1

摘要

研究了尿c肽升高的可能机制。Neprilysin抑制可阻断利钠肽的降解，并引起利钠和降压作用。抑制Neprilysin可能类似地阻断肾中c肽的降解，从而增加尿c肽水平。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Impact of the angiotensin receptor-neprilysin inhibitor in clinical diabetes management: Potential benefits and pitfalls

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Impact of the angiotensin receptor-neprilysin inhibitor in clinical diabetes management: Potential benefits and pitfalls

The possible mechanism of increased urinary C-peptide due to neprilysin inhibitors is investigated. Neprilysin inhibition blocks degradation of natriuretic peptides, and elicits a natriuretic and antihypertensive effect. Neprilysin inhibition might similarly block degradation of C-peptides in the kidney and thus increase the urinary C-peptide level.

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来源期刊

Journal of Diabetes Investigation Medicine-Internal Medicine

自引率

9.40%

发文量

218

期刊介绍： Journal of Diabetes Investigation is your core diabetes journal from Asia; the official journal of the Asian Association for the Study of Diabetes (AASD). The journal publishes original research, country reports, commentaries, reviews, mini-reviews, case reports, letters, as well as editorials and news. Embracing clinical and experimental research in diabetes and related areas, the Journal of Diabetes Investigation includes aspects of prevention, treatment, as well as molecular aspects and pathophysiology. Translational research focused on the exchange of ideas between clinicians and researchers is also welcome. Journal of Diabetes Investigation is indexed by Science Citation Index Expanded (SCIE).