环氧乙烷:危害表征和暴露反应分析

IF 1.2 4区 环境科学与生态学 Q4 ENVIRONMENTAL SCIENCES
R. Liteplo, M. E. Meek, W. Bruce
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引用次数: 1

摘要

环氧乙烷已被评估为优先物质根据加拿大环境保护法。根据对动物的研究,癌症被认为是环氧乙烷对人类健康影响的关键终点。在吸入性研究中,环氧乙烷已诱发多种肿瘤,其作用方式极有可能涉及与遗传物质的直接相互作用。致瘤浓度0.05(即,与高于背景的肿瘤发生率增加5%相关的浓度),来源于对具有最佳暴露反应特征的动物的研究,范围为2.2至31.0 mg/m3。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
ETHYLENE OXIDE: HAZARD CHARACTERIZATION AND EXPOSURE–RESPONSE ANALYSIS
Ethylene oxide has been assessed as a Priority Substance under the Canadian Environmental Protection Act. Based on studies in animals, cancer is considered the critical endpoint for effects of ethylene oxide on human health. In inhalation studies, ethylene oxide has induced a wide range of tumours, with a strong likelihood that the mode of action involves direct interaction with genetic material. Tumorigenic Concentration05s (i.e., concentrations associated with a 5% increase in tumour incidence above background), derived from a study in animals with optimal characterization of exposure–response, ranged from 2.2 to 31.0 mg/m3.
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来源期刊
CiteScore
4.60
自引率
0.00%
发文量
10
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