偶氮染料与人体健康研究进展

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2016-09-16 DOI:10.1080/10590501.2016.1236602

K. Chung

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引用次数: 547

摘要

合成偶氮染料在工业上有着广泛的应用。Gerhardt Domagk发现红色偶氮染料Prontosil的抗菌作用是由还原裂解(偶氮还原)产物磺胺引起的。从而揭示了偶氮还原的意义。偶氮还原可以通过人肠道菌群、皮肤菌群、环境微生物来完成，在较小程度上通过人肝脏偶氮还原酶来完成，也可以通过非生物手段来完成。有些偶氮染料即使没有被分解成芳香胺也会致癌。然而，许多偶氮染料的致癌性是由于它们的裂解产物，如联苯胺。联苯胺可诱发多种人类和动物肿瘤。另一种偶氮染料成分对苯二胺是一种接触性过敏原。据报道，许多偶氮染料及其还原裂解产物以及化学相关的芳香胺会影响人类健康，引起过敏和其他人类疾病。

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Azo dyes and human health: A review

ABSTRACT Synthetic azo dyes are widely used in industries. Gerhardt Domagk discovered that the antimicrobial effect of red azo dye Prontosil was caused by the reductively cleaved (azo reduction) product sulfanilamide. The significance of azo reduction is thus revealed. Azo reduction can be accomplished by human intestinal microflora, skin microflora, environmental microorganisms, to a lesser extent by human liver azoreductase, and by nonbiological means. Some azo dyes can be carcinogenic without being cleaved into aromatic amines. However, the carcinogenicity of many azo dyes is due to their cleaved product such as benzidine. Benzidine induces various human and animal tumors. Another azo dye component, p-phenylenediamine, is a contact allergen. Many azo dyes and their reductively cleaved products as well as chemically related aromatic amines are reported to affect human health, causing allergies and other human maladies.

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.