(±)-3-薄荷酮的硫代氨基脲和缩氨基脲衍生物的抗hiv活性

IF 4.3 3区医学 Q2 CHEMISTRY, MEDICINAL

Archiv der Pharmazie Pub Date : 2002-07-18 DOI:10.1002/1521-4184(200205)335:5<183::AID-ARDP183>3.0.CO;2-U

Vibha Mishra, S. N. Pandeya, Christophe Pannecouque, Myriam Witvrouw, E. De Clercq

引用次数: 60

摘要

合成了一系列(±)-3-薄荷酮的硫代氨基脲和缩氨基脲衍生物，并测定了它们对HIV-1(IIIB)和HIV-2 (ROD)的抗hiv活性。研究表明，氯取代衍生物2和7对HIV-1 (IIIB)和HIV-2 (ROD)具有最大的保护作用。

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Anti-HIV Activity of Thiosemicarbazone and Semicarbazone Derivatives of (±)-3-Menthone

A series of thiosemicarbazones and semicarbazone derivatives of (±)-3-menthone have been synthesized and their anti-HIV activity evaluated against HIV-1(III_B)and HIV-2 (ROD). The studies revealed that maximum protection is offered by chloro-substituted derivatives 2 and 7 against HIV-1 (III_B) and HIV-2 (ROD).

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来源期刊

Archiv der Pharmazie 医学-化学综合

CiteScore

7.90

自引率

5.90%

发文量

176

审稿时长

3.0 months

期刊介绍： Archiv der Pharmazie - Chemistry in Life Sciences is an international journal devoted to research and development in all fields of pharmaceutical and medicinal chemistry. Emphasis is put on papers combining synthetic organic chemistry, structural biology, molecular modelling, bioorganic chemistry, natural products chemistry, biochemistry or analytical methods with pharmaceutical or medicinal aspects such as biological activity. The focus of this journal is put on original research papers, but other scientifically valuable contributions (e.g. reviews, minireviews, highlights, symposia contributions, discussions, and essays) are also welcome.