妊娠期间母体代谢参数与妊娠20周至5岁胎儿和儿童生长轨迹之间的关系:来自ROLO纵向出生队列研究的二次分析

IF 2.7 3区医学 Q1 PEDIATRICS

Pediatric Obesity Pub Date : 2022-09-14 DOI:10.1111/ijpo.12976

Helena C. Bartels, Linda M. O'Keeffe, Cara A. Yelverton, Kate N. O'Neill, Aisling A. Geraghty, Eileen C. O'Brien, Sarah Louise Killeen, Ciara McDonnell, Fionnuala M. McAuliffe

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引用次数: 1

摘要

目的探讨妊娠期母体代谢参数与5岁前发育轨迹的关系。方法分析参与ROLO研究(一项随机试验，研究低血糖指数饮食对巨大儿复发的影响)的母子对数据。胎儿和儿童的生长轨迹是通过从妊娠20周到5岁的纵向测量来发展的。我们使用线性样条多层模型研究了妊娠早期(14-16周)和妊娠晚期(28周)孕妇空腹血糖、胰岛素、HOMA-IR和瘦素与体重(kg)和腹围(cm)轨迹之间的关系。结果我们没有发现任何母体代谢参数与胎儿到儿童体重和从妊娠20周到5岁的腹围轨迹之间的关联。结论:在一组有巨大儿风险的肥胖妇女中，从妊娠20周到5岁，母亲的代谢指标与体重或腹围的轨迹没有很强的相关性。

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Associations between maternal metabolic parameters during pregnancy and fetal and child growth trajectories from 20 weeks' gestation to 5 years of age: Secondary analysis from the ROLO longitudinal birth cohort study

Objective

To examine the association between maternal metabolic parameters in pregnancy and growth trajectories up to 5 years of age.

Methods

Data from mother–child pairs who participated in the ROLO study, a randomized trial examining the impact of a low glycaemic index diet on the recurrence of macrosomia, were analysed. Fetal and child growth trajectories were developed from longitudinal measurements from 20 weeks gestation up to 5 years of age. We examined associations between maternal fasting glucose, insulin, HOMA-IR and leptin, taken in early pregnancy (14–16 weeks) and late pregnancy (28 weeks), and weight (kg) and abdominal circumference (cm) trajectories using linear spline multilevel models.

Results

We found no strong evidence of associations between any maternal metabolic parameters and fetal to childhood weight and abdominal circumference trajectories from 20 weeks gestation to 5 years.

Conclusion

In a cohort of women with obesity with infants at risk of macrosomia, maternal metabolic markers were not strongly associated with trajectories of weight or abdominal circumference from 20 weeks gestation to 5 years of age.

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来源期刊

Pediatric Obesity PEDIATRICS-

CiteScore

7.30

自引率

5.30%

发文量

117

审稿时长

6-12 weeks

期刊介绍： Pediatric Obesity is a peer-reviewed, monthly journal devoted to research into obesity during childhood and adolescence. The topic is currently at the centre of intense interest in the scientific community, and is of increasing concern to health policy-makers and the public at large. Pediatric Obesity has established itself as the leading journal for high quality papers in this field, including, but not limited to, the following: Genetic, molecular, biochemical and physiological aspects of obesity – basic, applied and clinical studies relating to mechanisms of the development of obesity throughout the life course and the consequent effects of obesity on health outcomes Metabolic consequences of child and adolescent obesity Epidemiological and population-based studies of child and adolescent overweight and obesity Measurement and diagnostic issues in assessing child and adolescent adiposity, physical activity and nutrition Clinical management of children and adolescents with obesity including studies of treatment and prevention Co-morbidities linked to child and adolescent obesity – mechanisms, assessment, and treatment Life-cycle factors eg familial, intrauterine and developmental aspects of child and adolescent obesity Nutrition security and the "double burden" of obesity and malnutrition Health promotion strategies around the issues of obesity, nutrition and physical activity in children and adolescents Community and public health measures to prevent overweight and obesity in children and adolescents.