Determination of the mouse homologous region for the rat dmy locus

The autosomal recessive mutation dmy causes neurological changes which are characterized by a severe demyelination in the spinal cord, associated with paralysis of the hind limbs. Kuramoto et al. have already mapped the mutation between Hh1ltts and Agtr1a loci on rat chromosome 17 (Kuramoto et al. 1996). Toward the identification of the dmy mutation, we determined here the corresponding genomic region on mouse chromosome 13 and constructed its fine genetic and physical maps. We are currently producing further backcross progeny to narrow down the dmy interval on the rat genome. Determination of the homologous region on the mouse genome should help identifying the causative gene.