{"title":"在BB大鼠中，免疫系统的基因座与糖尿病的发病频率和年龄有关","authors":"I. Klöting, P. Kovács","doi":"10.1016/S0939-8600(00)80020-6","DOIUrl":null,"url":null,"abstract":"<div><p>The spontaneously diabetic BB rat is a well-established animal model in diabetes research developing an insulin-dependent type-1 diabetes mellitus closely resembling human diabetes. By several crossing studies using BB/OK rats it has been demonstrated that beside the MHC class-II genes of the RT1<sup>u</sup> haplotype, <em>Iddm1</em>, and the lymphopenia, <em>Iddm2</em>, at least two additional non-MHC genes located on chromosomes 6 (<em>Iddm4</em>) and 18 (<em>Iddm3</em>) are involved in diabetes development. In addition, there are at least three genes located on chromosomes 6 (<em>Dm1</em>), 8 (<em>Dm2</em>) and 10 (<em>Dm3</em>) influencing the age at onset of diabetes. Comparing the homologous regions between rat and human, it is shown that most diabetogenic genes lie on human chromosomes near genes involved in immune processes providing human geneticist with new candidate regions for the analysis of diabetogenic non-MHC genes in human type-1 diabetes.</p></div>","PeriodicalId":77206,"journal":{"name":"Journal of experimental animal science","volume":"41 1","pages":"Pages 19-21"},"PeriodicalIF":0.0000,"publicationDate":"2000-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0939-8600(00)80020-6","citationCount":"0","resultStr":"{\"title\":\"Loci of the immune system are implicated in diabetes frequency and age at onset of diabetes in BB rats\",\"authors\":\"I. Klöting, P. Kovács\",\"doi\":\"10.1016/S0939-8600(00)80020-6\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>The spontaneously diabetic BB rat is a well-established animal model in diabetes research developing an insulin-dependent type-1 diabetes mellitus closely resembling human diabetes. By several crossing studies using BB/OK rats it has been demonstrated that beside the MHC class-II genes of the RT1<sup>u</sup> haplotype, <em>Iddm1</em>, and the lymphopenia, <em>Iddm2</em>, at least two additional non-MHC genes located on chromosomes 6 (<em>Iddm4</em>) and 18 (<em>Iddm3</em>) are involved in diabetes development. In addition, there are at least three genes located on chromosomes 6 (<em>Dm1</em>), 8 (<em>Dm2</em>) and 10 (<em>Dm3</em>) influencing the age at onset of diabetes. Comparing the homologous regions between rat and human, it is shown that most diabetogenic genes lie on human chromosomes near genes involved in immune processes providing human geneticist with new candidate regions for the analysis of diabetogenic non-MHC genes in human type-1 diabetes.</p></div>\",\"PeriodicalId\":77206,\"journal\":{\"name\":\"Journal of experimental animal science\",\"volume\":\"41 1\",\"pages\":\"Pages 19-21\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2000-03-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1016/S0939-8600(00)80020-6\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of experimental animal science\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S0939860000800206\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of experimental animal science","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0939860000800206","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Loci of the immune system are implicated in diabetes frequency and age at onset of diabetes in BB rats
The spontaneously diabetic BB rat is a well-established animal model in diabetes research developing an insulin-dependent type-1 diabetes mellitus closely resembling human diabetes. By several crossing studies using BB/OK rats it has been demonstrated that beside the MHC class-II genes of the RT1u haplotype, Iddm1, and the lymphopenia, Iddm2, at least two additional non-MHC genes located on chromosomes 6 (Iddm4) and 18 (Iddm3) are involved in diabetes development. In addition, there are at least three genes located on chromosomes 6 (Dm1), 8 (Dm2) and 10 (Dm3) influencing the age at onset of diabetes. Comparing the homologous regions between rat and human, it is shown that most diabetogenic genes lie on human chromosomes near genes involved in immune processes providing human geneticist with new candidate regions for the analysis of diabetogenic non-MHC genes in human type-1 diabetes.
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