Carlos Escobar , Vivencio Barrios , Albert Ariza , Raquel Campuzano , José María Gámez , José María Mostaza
{"title":"贝登酸在血脂异常患者中的应用。实用的方法","authors":"Carlos Escobar , Vivencio Barrios , Albert Ariza , Raquel Campuzano , José María Gámez , José María Mostaza","doi":"10.1016/S1131-3587(21)00005-4","DOIUrl":null,"url":null,"abstract":"<div><p>The reduction in cholesterol levels obtained with lipid-lowering therapy is associated with a marked decrease in the risk of cardiovascular complications. However, a substantial proportion of patients with hypercholesterolemia do not achieve the recommended target level, irrespective of their cardiovascular risk. Although this is partly due to the intensity of lipid-lowering treatment being inadequate and although combination therapy could be prescribed more frequently, there is still a need for new drugs to help achieve therapeutic goals. Bempedoic acid is a new, first-in-class, oral, lipid-lowering drug that reduces cholesterol levels by inhibiting the enzyme adenosine triphosphate-citrate lyase, which plays a role in the cholesterol synthesis pathway upstream from where statins act. Importantly, bempedoic acid is not activated in skeletal muscle, which reduces the risk of muscle-related side effects. An extensive series of clinical trials has demonstrated the drug’s efficacy in reducing cholesterol levels when given as monotherapy or in combination with other lipid-lowering drugs. Moreover, its safety profile is good. In this document, a simple and easily applied algorithm is proposed for identifying those patients who potentially stand to benefit most from treatment with bempedoic acid. The algorithm takes into account cardiovascular risk, previous lipid-lowering therapy and the low-density lipoprotein cholesterol level. Its purpose is help the majority of patients achieve the treatment goals as soon as possible.</p></div>","PeriodicalId":34926,"journal":{"name":"Revista Espanola de Cardiologia Suplementos","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"3","resultStr":"{\"title\":\"Empleo del ácido bempedoico en los pacientes con dislipemia. Una aproximación práctica\",\"authors\":\"Carlos Escobar , Vivencio Barrios , Albert Ariza , Raquel Campuzano , José María Gámez , José María Mostaza\",\"doi\":\"10.1016/S1131-3587(21)00005-4\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>The reduction in cholesterol levels obtained with lipid-lowering therapy is associated with a marked decrease in the risk of cardiovascular complications. However, a substantial proportion of patients with hypercholesterolemia do not achieve the recommended target level, irrespective of their cardiovascular risk. Although this is partly due to the intensity of lipid-lowering treatment being inadequate and although combination therapy could be prescribed more frequently, there is still a need for new drugs to help achieve therapeutic goals. Bempedoic acid is a new, first-in-class, oral, lipid-lowering drug that reduces cholesterol levels by inhibiting the enzyme adenosine triphosphate-citrate lyase, which plays a role in the cholesterol synthesis pathway upstream from where statins act. Importantly, bempedoic acid is not activated in skeletal muscle, which reduces the risk of muscle-related side effects. An extensive series of clinical trials has demonstrated the drug’s efficacy in reducing cholesterol levels when given as monotherapy or in combination with other lipid-lowering drugs. Moreover, its safety profile is good. In this document, a simple and easily applied algorithm is proposed for identifying those patients who potentially stand to benefit most from treatment with bempedoic acid. The algorithm takes into account cardiovascular risk, previous lipid-lowering therapy and the low-density lipoprotein cholesterol level. Its purpose is help the majority of patients achieve the treatment goals as soon as possible.</p></div>\",\"PeriodicalId\":34926,\"journal\":{\"name\":\"Revista Espanola de Cardiologia Suplementos\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2021-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"3\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Revista Espanola de Cardiologia Suplementos\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S1131358721000054\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"Medicine\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Revista Espanola de Cardiologia Suplementos","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1131358721000054","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"Medicine","Score":null,"Total":0}
Empleo del ácido bempedoico en los pacientes con dislipemia. Una aproximación práctica
The reduction in cholesterol levels obtained with lipid-lowering therapy is associated with a marked decrease in the risk of cardiovascular complications. However, a substantial proportion of patients with hypercholesterolemia do not achieve the recommended target level, irrespective of their cardiovascular risk. Although this is partly due to the intensity of lipid-lowering treatment being inadequate and although combination therapy could be prescribed more frequently, there is still a need for new drugs to help achieve therapeutic goals. Bempedoic acid is a new, first-in-class, oral, lipid-lowering drug that reduces cholesterol levels by inhibiting the enzyme adenosine triphosphate-citrate lyase, which plays a role in the cholesterol synthesis pathway upstream from where statins act. Importantly, bempedoic acid is not activated in skeletal muscle, which reduces the risk of muscle-related side effects. An extensive series of clinical trials has demonstrated the drug’s efficacy in reducing cholesterol levels when given as monotherapy or in combination with other lipid-lowering drugs. Moreover, its safety profile is good. In this document, a simple and easily applied algorithm is proposed for identifying those patients who potentially stand to benefit most from treatment with bempedoic acid. The algorithm takes into account cardiovascular risk, previous lipid-lowering therapy and the low-density lipoprotein cholesterol level. Its purpose is help the majority of patients achieve the treatment goals as soon as possible.
期刊介绍:
Revista Española de Cardiología, is an international scientific journal dealing with cardiovascular medicine. Revista Española de Cardiología, the official publication of the Spanish Society of Cardiology, publishes research articles related to cardiovascular diseases. Articles are published in Spanish for the paper edition and in both Spanish and English in the electronic edition, which is available on the Internet. Regular sections include original articles reporting clinical or basic research, brief reports, review articles, editorials and letters to the Editor.