COVID-19患者心血管疾病的病理生理学。缺血、血栓形成和心脏功能障碍

Q4 Medicine
José Rozado , Ana Ayesta , César Morís , Pablo Avanzas
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引用次数: 12

摘要

心血管并发症在COVID-19患者中非常普遍,经常导致住院、死亡和长期发病率。本文描述了这些并发症发生的主要病理生理机制。初始病毒血症后,viralinvasión在肺部发生复制,伴随着免疫系统激活、细胞因子释放和促炎状态的诱导,出现败血症和多器官衰竭。心肌损伤可能是由于viralinvasión和局部炎症反应的直接作用,或不适当的全身炎症涉及细胞因子风暴的间接作用。此外,血栓形成前状态的发展,加上病毒引起的血管疾病,可能引发继发于微血管损伤或先前存在的动脉粥样硬化斑块不稳定的缺血和血栓形成事件。需要新的研究来揭示这些心血管事件的病理生理机制,并支持开发有效的新治疗方法。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Fisiopatología de la enfermedad cardiovascular en pacientes con COVID-19. Isquemia, trombosis y disfunción cardiaca

Cardiovascular complications are highly prevalent in patients with COVID-19 and frequently lead to hospitalization, death and long-term morbidity. This article describes the principle pathophysiological mechanisms involved in the development of these complications. After the initial viremia, viralinvasión and replication occurs in the lungs, accompanied by immune system activation, cytokine release and the induction of a proinflammatory state, with sepsis and multiorgan failure. Myocardial injury could be due to the direct effect of viralinvasión and a local inflammatory response or to the indirect effect of inappropriate systemic inflammation involving a cytokine storm. Furthermore, the development of a prothrombotic state, together with vascular disease due to the virus, could trigger ischemic and thrombotic events secondary to microvascular damage or to the destabilization of pre-existing atheromatous plaque. New research is needed to reveal the pathophysiological mechanisms underlying these cardiovascular events and to support the development of effective new treatments.

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来源期刊
Revista Espanola de Cardiologia Suplementos
Revista Espanola de Cardiologia Suplementos Medicine-Cardiology and Cardiovascular Medicine
CiteScore
1.20
自引率
0.00%
发文量
1
期刊介绍: Revista Española de Cardiología, is an international scientific journal dealing with cardiovascular medicine. Revista Española de Cardiología, the official publication of the Spanish Society of Cardiology, publishes research articles related to cardiovascular diseases. Articles are published in Spanish for the paper edition and in both Spanish and English in the electronic edition, which is available on the Internet. Regular sections include original articles reporting clinical or basic research, brief reports, review articles, editorials and letters to the Editor.
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