阿尔茨海默病中的突变tau蛋白、淀粉样蛋白和神经炎症

Q Medicine

Progress in Histochemistry and Cytochemistry Pub Date : 2016-05-01 DOI:10.1016/j.proghi.2016.01.001

A.S.M. Hung , Y. Liang , Tony C.H. Chow , H.C. Tang , Sharon L.Y. Wu , M.S.M. Wai , D.T. Yew

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引用次数: 38

摘要

本文综述了tau、淀粉样蛋白、神经炎症因子和小胶质细胞突变在阿尔茨海默病中的重要性。特别是tau、CD4和TNF α被纳入到综述中，并强调了这些因子的共定位。认识到阿尔茨海默病可能是这些因素相互作用的结果是很重要的。其中一些因素可能在同一区域和同一时间共存，例如斑块中的tau和淀粉样蛋白突变。包括导致该疾病的病原学总结方案。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Mutated tau, amyloid and neuroinflammation in Alzheimer disease—A brief review

This review discussed the importance of mutated tau, amyloid and neuroinflammatory factors and microglia in Alzheimer disease. In particular tau, CD4 and TNF alpha were included in the review and the colocalizations of these factors were highlighted. It is important to realize the Alzheimer disease may result from the interactions of these factors. Some of these factors may coexist at the same region and at the same time e.g. mutated tau and amyloid in plaques. A summary scheme of etiology leading to the disease was included.

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来源期刊

Progress in Histochemistry and Cytochemistry 生物-细胞生物学

CiteScore

4.67

自引率

0.00%

发文量

审稿时长

>12 weeks

期刊介绍： Progress in Histochemistry and Cytochemistry publishes comprehensive and analytical reviews within the entire field of histochemistry and cytochemistry. Methodological contributions as well as papers in the fields of applied histo- and cytochemistry (e.g. cell biology, pathology, clinical disciplines) will be accepted.