E. Albert Vicent, R. Ferriols Lisart, M.A. Roch Ventura, M. Alós Almiñana
{"title":"地高辛测试与Architect®i1000 sr系统与AxSYM®系统的比较","authors":"E. Albert Vicent, R. Ferriols Lisart, M.A. Roch Ventura, M. Alós Almiñana","doi":"10.1016/j.farmae.2011.02.001","DOIUrl":null,"url":null,"abstract":"<div><h3>Objective</h3><p>To assess the technique employed by the autoanalyser Architect<sup>®</sup> i1000<!--> <span>sr to determine digoxin in serum samples, compared with the assay developed for AsSYM</span><sup>®</sup><span> using microparticle enzyme immunoassay (Digoxin II).</span></p></div><div><h3>Method</h3><p>A prospective analysis of the samples from 100 requests to monitor patients being treated with digoxin. The samples were processed in AxSYM<sup>®</sup> and Architect<sup>®</sup>. The techniques were assessed using the linear regression coefficient, determination coefficient, mean absolute error, mean squared prediction error and the Bland-Altman method.</p></div><div><h3>Results</h3><p>The serum levels showed a correlation coefficient of 0.93. There was nearly a 40% difference for the concentrations between 0.8 and 2<!--> <!-->ng/ml and nearly 20% in the rest of the samples analysed.</p></div><div><h3>Conclusions</h3><p>The Architect<sup>®</sup> system is precise; however, from a clinical monitoring point of view, it is unacceptably inaccurate when compared with the AxSYM<sup>®</sup>.</p></div>","PeriodicalId":100521,"journal":{"name":"Farmacia Hospitalaria (English Edition)","volume":"35 5","pages":"Pages 256-259"},"PeriodicalIF":0.0000,"publicationDate":"2011-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.farmae.2011.02.001","citationCount":"0","resultStr":"{\"title\":\"Comparing the Digoxin Test With the Architect®i1000 sr System With Respect to the AxSYM® System\",\"authors\":\"E. Albert Vicent, R. Ferriols Lisart, M.A. Roch Ventura, M. Alós Almiñana\",\"doi\":\"10.1016/j.farmae.2011.02.001\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Objective</h3><p>To assess the technique employed by the autoanalyser Architect<sup>®</sup> i1000<!--> <span>sr to determine digoxin in serum samples, compared with the assay developed for AsSYM</span><sup>®</sup><span> using microparticle enzyme immunoassay (Digoxin II).</span></p></div><div><h3>Method</h3><p>A prospective analysis of the samples from 100 requests to monitor patients being treated with digoxin. The samples were processed in AxSYM<sup>®</sup> and Architect<sup>®</sup>. The techniques were assessed using the linear regression coefficient, determination coefficient, mean absolute error, mean squared prediction error and the Bland-Altman method.</p></div><div><h3>Results</h3><p>The serum levels showed a correlation coefficient of 0.93. There was nearly a 40% difference for the concentrations between 0.8 and 2<!--> <!-->ng/ml and nearly 20% in the rest of the samples analysed.</p></div><div><h3>Conclusions</h3><p>The Architect<sup>®</sup> system is precise; however, from a clinical monitoring point of view, it is unacceptably inaccurate when compared with the AxSYM<sup>®</sup>.</p></div>\",\"PeriodicalId\":100521,\"journal\":{\"name\":\"Farmacia Hospitalaria (English Edition)\",\"volume\":\"35 5\",\"pages\":\"Pages 256-259\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2011-09-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1016/j.farmae.2011.02.001\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Farmacia Hospitalaria (English Edition)\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S2173508511000396\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Farmacia Hospitalaria (English Edition)","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2173508511000396","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Comparing the Digoxin Test With the Architect®i1000 sr System With Respect to the AxSYM® System
Objective
To assess the technique employed by the autoanalyser Architect® i1000 sr to determine digoxin in serum samples, compared with the assay developed for AsSYM® using microparticle enzyme immunoassay (Digoxin II).
Method
A prospective analysis of the samples from 100 requests to monitor patients being treated with digoxin. The samples were processed in AxSYM® and Architect®. The techniques were assessed using the linear regression coefficient, determination coefficient, mean absolute error, mean squared prediction error and the Bland-Altman method.
Results
The serum levels showed a correlation coefficient of 0.93. There was nearly a 40% difference for the concentrations between 0.8 and 2 ng/ml and nearly 20% in the rest of the samples analysed.
Conclusions
The Architect® system is precise; however, from a clinical monitoring point of view, it is unacceptably inaccurate when compared with the AxSYM®.
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