近交系C57Bl/6J小鼠抗体应答的个体差异及其与野外行为个体差异的关系

IF 0.6 Q4 PSYCHOLOGY

Anuario de Psicologia Pub Date : 2017-01-01 DOI:10.1016/j.anpsic.2017.05.002

José Vidal

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引用次数: 0

摘要

自交系C57Bl/6J小鼠对热聚集牛血清白蛋白的IgG类抗体反应表现出较高的变异性。聚类分析(以1相关系数作为距离)揭示了两组小鼠:产生增强二抗反应的小鼠和没有增强二抗反应的小鼠;对上述各组进行的另一聚类分析(以抗体浓度作为距离的差异)揭示了具有不同抗体含量的小群小鼠或单个小鼠。抗体浓度与野外行走、饲养、梳理或排便无关，但行走与饲养呈正相关。

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Individual differences in the antibody response of inbred C57Bl/6J mice and their relation to individual differences in open-field behavior

Mice of the inbred C57Bl/6J strain displayed high variability in the antibody response of the IgG class to heat-aggregated bovine serum albumin. A cluster analysis (with 1-correlation coefficient as distance) disclosed two groups of mice: those mice than produced an augmented secondary antibody response, and those that did not; another cluster analysis (with difference in antibody concentration as distance) on each of the above groups disclosed small groups of mice, or individual mice, with varying antibody content. Antibody concentration was not associated with ambulation, rearing, grooming, or defecation in the open-field, but ambulation was positively correlated with rearing.

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来源期刊

Anuario de Psicologia Multiple-

CiteScore

0.80

自引率

40.00%

发文量

期刊介绍： The Anuario de Psicología, one of Spain"s most important general psychology journals, is published by the Faculty of Psychology of the University of Barcelona. It appears three times a year. The Anuario combines continuity with the past with a strong commitment to the present and the future. The journal is broad-ranging, interdisciplinary, and innovative. The Anuario publishes research reports and applied studies in all fields of psychology. We also accept theorical, epistemological studies, organize dossiers on topical themes, and hold debates on controversial subjects deriving from a central article.