Shihori Tanabe, Danielle Beaton, Vinita Chauhan, Ian Choi, Judy Choi, Laure-Alix Clerbaux, Lucia Coppola, Antonio Fernandez Dumont, Maranda Esterhuizen, Julija Filipovska, Rex FitzGerald, Ellen Fritsche, Natalia Garcia-Reyero, Anna Goralczyk, Elizabeth Huliganga, Young-Jun Kim, Jördis Klose, Cinzia La Rocca, Brigitte Landesmann, Angela Mally, Sivakumar Murugadoss, Elma Omeragic, Gladys Ouédraogo, Jorge Matias Pereira, Baki Sadi, Alexandra Schaffert, You Song, Iva Sovadinova, Tobias Stöger, Knut Erik Tollefsen, Clemens Wittwehr, Carole Yauk
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Report of the 3rd and 4th Mystery of Reactive Oxygen Species Conference.
The main MoR discussion led to further suggestions on KE terminology, including ensuring coherence to directionality in terms of the KE descriptions (e.g., specifying increase, decrease, altered, no direction, etc.) and clarifying differences in ROS and reactive oxygen and nitrogen species (RONS), and enzymatic and non-enzymatic events. The consortium highlighted the importance of the role of ROS as a KE and an associative event in the AOP framework. Additionally, participants highlighted modification to macromolecules from the resultant RONS generation (e.g., lipid peroxidation) as a relevant endpoint to include in the KE. The possibility of grouping ROS-related KEs in the AOP framework needs to be discussed further.
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ALTEX publishes original articles, short communications, reviews, as well as news and comments and meeting reports. Manuscripts submitted to ALTEX are evaluated by two expert reviewers. The evaluation takes into account the scientific merit of a manuscript and its contribution to animal welfare and the 3R principle.
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