胶质母细胞瘤微环境的异质性和个体化治疗（综述）。

IF 3.8 3区医学 Q2 ONCOLOGY

Oncology reports Pub Date : 2023-12-01 Epub Date: 2023-10-27 DOI:10.3892/or.2023.8654

Wei Kang, Zhixiao Mo, Wenshan Li, Haifeng Ma, Qiang Zhang

{"title":"胶质母细胞瘤微环境的异质性和个体化治疗（综述）。","authors":"Wei Kang, Zhixiao Mo, Wenshan Li, Haifeng Ma, Qiang Zhang","doi":"10.3892/or.2023.8654","DOIUrl":null,"url":null,"abstract":"The heterogeneity of glioblastoma can suppress immune cell function and lead to immune evasion, which presents a challenge in developing effective molecular therapies for tumor cells. However, the study of tumor immune heterogeneity holds great potential for clinical immunotherapy. Liquid biopsy is a useful tool for accurately monitoring dynamic changes in tumor immune heterogeneity and the tumor microenvironment. This paper explores the heterogeneity of glioblastoma and the immune microenvironment, providing a therapeutic basis for individualized treatment. Using liquid biopsy technology as a new diagnostic method, innovative treatment strategies may be implemented for patients with glioblastoma to improve their outcomes.","PeriodicalId":19527,"journal":{"name":"Oncology reports","volume":"50 6","pages":""},"PeriodicalIF":3.8000,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10636722/pdf/","citationCount":"0","resultStr":"{\"title\":\"Heterogeneity and individualized treatment of microenvironment in glioblastoma (Review).\",\"authors\":\"Wei Kang, Zhixiao Mo, Wenshan Li, Haifeng Ma, Qiang Zhang\",\"doi\":\"10.3892/or.2023.8654\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"The heterogeneity of glioblastoma can suppress immune cell function and lead to immune evasion, which presents a challenge in developing effective molecular therapies for tumor cells. However, the study of tumor immune heterogeneity holds great potential for clinical immunotherapy. Liquid biopsy is a useful tool for accurately monitoring dynamic changes in tumor immune heterogeneity and the tumor microenvironment. This paper explores the heterogeneity of glioblastoma and the immune microenvironment, providing a therapeutic basis for individualized treatment. Using liquid biopsy technology as a new diagnostic method, innovative treatment strategies may be implemented for patients with glioblastoma to improve their outcomes.\",\"PeriodicalId\":19527,\"journal\":{\"name\":\"Oncology reports\",\"volume\":\"50 6\",\"pages\":\"\"},\"PeriodicalIF\":3.8000,\"publicationDate\":\"2023-12-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10636722/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Oncology reports\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.3892/or.2023.8654\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2023/10/27 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"Q2\",\"JCRName\":\"ONCOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Oncology reports","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.3892/or.2023.8654","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2023/10/27 0:00:00","PubModel":"Epub","JCR":"Q2","JCRName":"ONCOLOGY","Score":null,"Total":0}

引用次数: 0

摘要

胶质母细胞瘤的异质性会抑制免疫细胞功能并导致免疫逃避，这对开发有效的肿瘤细胞分子疗法提出了挑战。然而，肿瘤免疫异质性的研究在临床免疫治疗中具有巨大的潜力。液体活检是准确监测肿瘤免疫异质性和肿瘤微环境动态变化的有用工具。本文探讨了胶质母细胞瘤的异质性和免疫微环境，为个体化治疗提供了治疗基础。使用液体活检技术作为一种新的诊断方法，可以对胶质母细胞瘤患者实施创新的治疗策略，以改善他们的预后。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

Heterogeneity and individualized treatment of microenvironment in glioblastoma (Review).

The heterogeneity of glioblastoma can suppress immune cell function and lead to immune evasion, which presents a challenge in developing effective molecular therapies for tumor cells. However, the study of tumor immune heterogeneity holds great potential for clinical immunotherapy. Liquid biopsy is a useful tool for accurately monitoring dynamic changes in tumor immune heterogeneity and the tumor microenvironment. This paper explores the heterogeneity of glioblastoma and the immune microenvironment, providing a therapeutic basis for individualized treatment. Using liquid biopsy technology as a new diagnostic method, innovative treatment strategies may be implemented for patients with glioblastoma to improve their outcomes.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

Oncology reports 医学-肿瘤学

CiteScore

8.50

自引率

2.40%

发文量

187

审稿时长

3 months

期刊介绍： Oncology Reports is a monthly, peer-reviewed journal devoted to the publication of high quality original studies and reviews concerning a broad and comprehensive view of fundamental and applied research in oncology, focusing on carcinogenesis, metastasis and epidemiology.