{"title":"吡唑并嘧啶作为靶向抗癌支架——综述。","authors":"Kesavamoorthy Kandhasamy, Remya Ramachandran Surajambika, Pradeep Kumar Velayudham","doi":"10.2174/0115734064251256231018104623","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Globally, cancer is the leading cause of death, which causes 10 million deaths yearly. Clinically, several drugs are used in treatment but due to drug resistance and multidrug resistance, there occurs a failure in the cancer treatment.</p><p><strong>Objectives: </strong>The present review article is a comprehensive review of pyrazole and pyrimidine hybrids as potential anticancer agents.</p><p><strong>Methods: </strong>The review comprises more than 60 research works done in this field. The efficiency of the reported pyrazolopyrimidine fused heterocyclic with their biological data and the influence of the structural aspects of the molecule have been discussed.</p><p><strong>Results: </strong>This review highlighted pyrazolo-pyrimidines as targeted anticancer agents with effect on multiple targets.</p><p><strong>Conclusion: </strong>The review will be helpful for the researchers involved in targeted drugs for cancer therapy for designing new scaffolds with pyrazolo-pyrimidine moieties.</p>","PeriodicalId":18382,"journal":{"name":"Medicinal Chemistry","volume":null,"pages":null},"PeriodicalIF":1.9000,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Pyrazolo - Pyrimidines as Targeted Anticancer Scaffolds - A Comprehensive Review.\",\"authors\":\"Kesavamoorthy Kandhasamy, Remya Ramachandran Surajambika, Pradeep Kumar Velayudham\",\"doi\":\"10.2174/0115734064251256231018104623\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>Globally, cancer is the leading cause of death, which causes 10 million deaths yearly. Clinically, several drugs are used in treatment but due to drug resistance and multidrug resistance, there occurs a failure in the cancer treatment.</p><p><strong>Objectives: </strong>The present review article is a comprehensive review of pyrazole and pyrimidine hybrids as potential anticancer agents.</p><p><strong>Methods: </strong>The review comprises more than 60 research works done in this field. The efficiency of the reported pyrazolopyrimidine fused heterocyclic with their biological data and the influence of the structural aspects of the molecule have been discussed.</p><p><strong>Results: </strong>This review highlighted pyrazolo-pyrimidines as targeted anticancer agents with effect on multiple targets.</p><p><strong>Conclusion: </strong>The review will be helpful for the researchers involved in targeted drugs for cancer therapy for designing new scaffolds with pyrazolo-pyrimidine moieties.</p>\",\"PeriodicalId\":18382,\"journal\":{\"name\":\"Medicinal Chemistry\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":1.9000,\"publicationDate\":\"2024-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Medicinal Chemistry\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.2174/0115734064251256231018104623\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"CHEMISTRY, MEDICINAL\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Medicinal Chemistry","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.2174/0115734064251256231018104623","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"CHEMISTRY, MEDICINAL","Score":null,"Total":0}
Pyrazolo - Pyrimidines as Targeted Anticancer Scaffolds - A Comprehensive Review.
Background: Globally, cancer is the leading cause of death, which causes 10 million deaths yearly. Clinically, several drugs are used in treatment but due to drug resistance and multidrug resistance, there occurs a failure in the cancer treatment.
Objectives: The present review article is a comprehensive review of pyrazole and pyrimidine hybrids as potential anticancer agents.
Methods: The review comprises more than 60 research works done in this field. The efficiency of the reported pyrazolopyrimidine fused heterocyclic with their biological data and the influence of the structural aspects of the molecule have been discussed.
Results: This review highlighted pyrazolo-pyrimidines as targeted anticancer agents with effect on multiple targets.
Conclusion: The review will be helpful for the researchers involved in targeted drugs for cancer therapy for designing new scaffolds with pyrazolo-pyrimidine moieties.
期刊介绍：
Aims & Scope
Medicinal Chemistry a peer-reviewed journal, aims to cover all the latest outstanding developments in medicinal chemistry and rational drug design. The journal publishes original research, mini-review articles and guest edited thematic issues covering recent research and developments in the field. Articles are published rapidly by taking full advantage of Internet technology for both the submission and peer review of manuscripts. Medicinal Chemistry is an essential journal for all involved in drug design and discovery.
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