用于生物大分子（MIPs）、病毒（VIP）和细胞（CIPs）的质体抗体途径上的印迹聚合物。

4区工程技术 Q2 Biochemistry, Genetics and Molecular Biology

Advances in biochemical engineering/biotechnology Pub Date : 2024-01-01 DOI:10.1007/10_2023_234

Xiaorong Zhang, Aysu Yarman, Mahdien Bagheri, Ibrahim M El-Sherbiny, Rabeay Y A Hassan, Sevinc Kurbanoglu, Armel Franklin Tadjoung Waffo, Ingo Zebger, Tutku Ceren Karabulut, Frank F Bier, Peter Lieberzeit, Frieder W Scheller

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引用次数: 0

摘要

大约30%发表在印迹聚合物上的科学论文描述了对蛋白质、核酸、病毒和细胞的识别。与酶或抗体相比，仅由一种至六种功能单体直接合成以及简单地整合到传感器中是显著的优势。此外，它们可以针对毒性物质和低免疫原性结构进行合成，并允许通过多模板合成进行多分析物测量。对于蛋白质生物标志物、DNA、病毒和细胞来说，亲和力足够高。然而，高丰度蛋白质的交叉反应性仍然是一个挑战。

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Imprinted Polymers on the Route to Plastibodies for Biomacromolecules (MIPs), Viruses (VIPs), and Cells (CIPs).

Around 30% of the scientific papers published on imprinted polymers describe the recognition of proteins, nucleic acids, viruses, and cells. The straightforward synthesis from only one up to six functional monomers and the simple integration into a sensor are significant advantages as compared with enzymes or antibodies. Furthermore, they can be synthesized against toxic substances and structures of low immunogenicity and allow multi-analyte measurements via multi-template synthesis. The affinity is sufficiently high for protein biomarkers, DNA, viruses, and cells. However, the cross-reactivity of highly abundant proteins is still a challenge.

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来源期刊

Advances in biochemical engineering/biotechnology 工程技术-生物工程与应用微生物

CiteScore

5.70

自引率

0.00%

发文量

期刊介绍： Advances in Biochemical Engineering/Biotechnology reviews actual trends in modern biotechnology. Its aim is to cover all aspects of this interdisciplinary technology where knowledge, methods and expertise are required for chemistry, biochemistry, microbiology, genetics, chemical engineering and computer science. Special volumes are dedicated to selected topics which focus on new biotechnological products and new processes for their synthesis and purification. They give the state-of-the-art of a topic in a comprehensive way thus being a valuable source for the next 3 - 5 years. It also discusses new discoveries and applications.