干细胞治疗甲状腺疾病:进展和挑战

IF 1.6 Q3 MEDICINE, RESEARCH & EXPERIMENTAL

Current Therapeutic Research-clinical and Experimental Pub Date : 2022-01-01 DOI:10.1016/j.curtheres.2022.100665

Sunyi Ye Ph.D., Zhu Lixian M.D.

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引用次数: 2

摘要

甲状腺激素是器官发育和维持体内平衡不可或缺的激素。甲状腺疾病，包括甲状腺炎和甲状腺癌，影响激素的正常分泌，导致甲状腺功能障碍。目的综述干细胞在甲状腺疾病治疗中的应用。方法检索Medline和PubMed的文献(2000年1月至2021年7月)，以确定干细胞治疗甲状腺疾病的最新报道。结果干细胞是部分发育的细胞类型。它们有能力形成专门的细胞。除了胚胎干细胞和间充质干细胞外，器官常驻干细胞和癌症干细胞在器官特异性细胞和癌症的形成中也有重要的作用。干细胞，尤其是间充质干细胞，具有抗炎和抗癌的功能。结论综述了胚胎干细胞、间充质干细胞、甲状腺常驻干细胞和甲状腺癌干细胞在甲状腺细胞再生、甲状腺功能调节、甲状腺炎抑制和抗甲状腺癌等方面的治疗作用。干细胞是治疗甲状腺疾病的一种很有前途的方法。

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Stem Cell Therapy for Thyroid Diseases: Progress and Challenges

Background

Thyroid hormones are indispensable for organ development and maintaining homeostasis. Thyroid diseases, including thyroiditis and thyroid cancer, affect the normal secretion of hormones and result in thyroid dysfunction.

Objective

This review focuses on therapeutic applications of stem cells for thyroid diseases.

Methods

A literature search of Medline and PubMed was conducted (January 2000–July 2021) to identify recent reports on stem cell therapy for thyroid diseases.

Results

Stem cells are partially developed cell types. They have the capacity to form specialized cells. Besides embryonic stem cells and mesenchymal stem cells, organ resident stem cells and cancer stem cells are recently reported to have important roles in forming organ specific cells and cancers. Stem cells, especially mesenchymal stem cells, have anti-inflammatory and anticancer functions as well.

Conclusions

This review outlines the therapeutic potency of embryonic stem cells, mesenchymal stem cells, thyroid resident stem cells, and thyroid cancer stem cells in thyroid cells’ regeneration, thyroid function modulation, thyroiditis suppression, and antithyroid cancers. Stem cells represent a promising form of treatment for thyroid disorders.

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来源期刊

Current Therapeutic Research-clinical and Experimental 医学-药学

CiteScore

3.50

自引率

0.00%

发文量

审稿时长

3 months

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