发育期间长期口服辣椒素暴露导致成年大鼠味蕾体积减少

IF 1 4区 医学 Q4 Neuroscience
Jacquelyn M. Omelian, Kaeli K. Samson, Suzanne I. Sollars
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引用次数: 2

摘要

味觉神经和三叉神经之间的交叉感觉相互作用发生在舌头前部。手术操作表明,这种关系的强度随发育而变化。辣椒素是一种影响味蕾周围体感舌神经纤维的神经毒素,但不影响与味觉受体细胞突触的味觉脊索鼓室神经纤维。由于辣椒素通常被包括人类在内的许多物种食用,这种神经毒素的实验使用提供了舌三叉神经系统的自然扰动。新生或成年大鼠口服辣椒素40?我们研究了在整个发育过程中对味蕾形态的交叉感觉效应。大鼠接受中等剂量的口服辣椒素,在味觉系统成熟之前或之后进行慢性治疗。舌形态检查2或50?停止治疗后的天数。水肿,先前被认为是辣椒素相关味觉功能改变的原因,也被评估。味蕾体积减少了50?天,但不是2天?大鼠作为新生儿处理后的天数。成年大鼠在治疗后的任何时间都不受影响。没有发现水肿与5?我们使用的辣椒素的PPM浓度。结果进一步阐明了这些离散感觉系统之间的合作关系,并强调了这种相互作用的发育介导方面。在发育过程中,长期暴露于即使是中等水平的有害刺激也会影响口腔感觉环境,而且这些变化可能在暴露停止很久之后才会明显。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Chronic Oral Capsaicin Exposure During Development Leads to Adult Rats with Reduced Taste Bud Volumes

Chronic Oral Capsaicin Exposure During Development Leads to Adult Rats with Reduced Taste Bud Volumes

A cross-sensory interaction between gustatory and trigeminal nerves occurs in the anterior tongue. Surgical manipulations have demonstrated that the strength of this relationship varies across development. Capsaicin is a neurotoxin that affects fibers of the somatosensory lingual nerve surrounding taste buds, but not fibers of the gustatory chorda tympani nerve which synapse with taste receptor cells. Since capsaicin is commonly consumed by many species, including humans, the experimental use of this neurotoxin provides a naturalistic perturbation of the lingual trigeminal system. Neonatal or adult rats consumed oral capsaicin for 40?days, and we examined the cross-sensory effect on the morphology of taste buds across development.

Rats received moderate doses of oral capsaicin, with chronic treatments occurring either before or after taste system maturation. Tongue morphology was examined either 2 or 50?days after treatment cessation. Edema, which has been previously suggested as a cause of changes in capsaicin-related gustatory function, was also assessed.

Reductions in taste bud volume occurred 50?days, but not 2?days post-treatment for rats treated as neonates. Adult rats at either time post-treatment were unaffected. Edema was not found to occur with the 5?ppm concentration of capsaicin we used.

Results further elucidate the cooperative relationship between these discrete sensory systems and highlight the developmentally mediated aspect of this interaction.

Chronic exposure to even moderate levels of noxious stimuli during development has the ability to impact the orosensory environment, and these changes may not be evident until long after exposure has ceased.

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来源期刊
Chemosensory Perception
Chemosensory Perception 农林科学-神经科学
CiteScore
2.50
自引率
0.00%
发文量
8
审稿时长
>36 weeks
期刊介绍: Coverage in Chemosensory Perception includes animal work with implications for human phenomena and explores the following areas: Identification of chemicals producing sensory response; Identification of sensory response associated with chemicals; Human in vivo response to chemical stimuli; Human in vitro response to chemical stimuli; Neuroimaging of chemosensory function; Neurological processing of chemoreception; Chemoreception mechanisms; Psychophysics of chemoperception; Trigeminal function; Multisensory perception; Contextual effect on chemoperception; Behavioral response to chemical stimuli; Physiological factors affecting and contributing to chemoperception; Flavor and hedonics; Memory and chemoperception.
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