作为细胞系统的全氟碳纳米颗粒对血液的影响

IF 1.1 Q4 CELL BIOLOGY

Biochemistry (Moscow), Supplement Series A: Membrane and Cell Biology Pub Date : 2023-03-29 DOI:10.1134/S1990747823010051

I. N. Kuznetsova, A. Yu. Lyanguzov

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引用次数: 0

摘要

摘要:研究了全氟化碳纳米颗粒对血细胞功能的影响。有证据表明，小体积乳化的PFC纳米颗粒会影响血液的气体输送功能，增加氧气从红细胞向组织的扩散速度。研究发现，PFC纳米颗粒也以剂量依赖的方式影响血细胞(红细胞、白细胞和血小板)的状态。根据乳状液剂量的不同，即细胞周围纳米颗粒的密度，受体装置的反应可引起其功能的激活或恶化。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

The Effect of Perfluorocarbon Nanoparticles on Blood As a Cellular System

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The Effect of Perfluorocarbon Nanoparticles on Blood As a Cellular System

Abstract—

The effect of perfluorocarbon (PFC) nanoparticles on the functioning of blood cells is considered. Evidence is presented indicating that emulsified PFC nanoparticles in small volumes affect gas transport function of blood, increasing the rate of oxygen diffusion from erythrocytes to tissues. It was found that PFC nanoparticles also affect the state of blood cells (erythrocytes, leukocytes, and platelets) in a dose-dependent manner. It was assumed that depending on the emulsion dose, that is, the density of nanoparticles in the surrounding space of cells, the reaction of receptor apparatus can cause activation or deterioration of their functioning.

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来源期刊

Biochemistry (Moscow), Supplement Series A: Membrane and Cell Biology CELL BIOLOGY-

CiteScore

1.40

自引率

0.00%

发文量

期刊介绍： Biochemistry (Moscow), Supplement Series A: Membrane and Cell Biology is an international peer reviewed journal that publishes original articles on physical, chemical, and molecular mechanisms that underlie basic properties of biological membranes and mediate membrane-related cellular functions. The primary topics of the journal are membrane structure, mechanisms of membrane transport, bioenergetics and photobiology, intracellular signaling as well as membrane aspects of cell biology, immunology, and medicine. The journal is multidisciplinary and gives preference to those articles that employ a variety of experimental approaches, basically in biophysics but also in biochemistry, cytology, and molecular biology. The journal publishes articles that strive for unveiling membrane and cellular functions through innovative theoretical models and computer simulations.