{"title":"丙型肝炎病毒和其他黄病毒RNA基因组内核糖体进入位点","authors":"Stanley M. Lemon , Masao Honda","doi":"10.1006/smvy.1997.0129","DOIUrl":null,"url":null,"abstract":"<div><p>The 5′ nontranslated RNAs of hepatitis C virus (HCV) and several other members of the<em>Flaviviridae</em>contain highly structured segments which form internal ribosome entry sites (IRESs). These<em>cis</em>-active RNA elements direct the cap-independent initiation of translation of the viral polyprotein in association with<em>trans</em>-acting cellular and possibly viral proteins, and thus they play a key role in the replication of the virus. The structure of the HCV IRES does not resemble that of any picornaviral IRES, and its function is uniquely dependent upon RNA sequence extending 3′ of the site of translation initiation as well as structure surrounding the initiator AUG.</p></div>","PeriodicalId":92955,"journal":{"name":"Seminars in virology","volume":"8 3","pages":"Pages 274-288"},"PeriodicalIF":0.0000,"publicationDate":"1997-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1006/smvy.1997.0129","citationCount":"83","resultStr":"{\"title\":\"Internal Ribosome Entry Sites within the RNA Genomes of Hepatitis C Virus and Other Flaviviruses\",\"authors\":\"Stanley M. Lemon , Masao Honda\",\"doi\":\"10.1006/smvy.1997.0129\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>The 5′ nontranslated RNAs of hepatitis C virus (HCV) and several other members of the<em>Flaviviridae</em>contain highly structured segments which form internal ribosome entry sites (IRESs). These<em>cis</em>-active RNA elements direct the cap-independent initiation of translation of the viral polyprotein in association with<em>trans</em>-acting cellular and possibly viral proteins, and thus they play a key role in the replication of the virus. The structure of the HCV IRES does not resemble that of any picornaviral IRES, and its function is uniquely dependent upon RNA sequence extending 3′ of the site of translation initiation as well as structure surrounding the initiator AUG.</p></div>\",\"PeriodicalId\":92955,\"journal\":{\"name\":\"Seminars in virology\",\"volume\":\"8 3\",\"pages\":\"Pages 274-288\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1997-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1006/smvy.1997.0129\",\"citationCount\":\"83\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Seminars in virology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S1044577397901293\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Seminars in virology","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1044577397901293","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Internal Ribosome Entry Sites within the RNA Genomes of Hepatitis C Virus and Other Flaviviruses
The 5′ nontranslated RNAs of hepatitis C virus (HCV) and several other members of theFlaviviridaecontain highly structured segments which form internal ribosome entry sites (IRESs). Thesecis-active RNA elements direct the cap-independent initiation of translation of the viral polyprotein in association withtrans-acting cellular and possibly viral proteins, and thus they play a key role in the replication of the virus. The structure of the HCV IRES does not resemble that of any picornaviral IRES, and its function is uniquely dependent upon RNA sequence extending 3′ of the site of translation initiation as well as structure surrounding the initiator AUG.
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