Ruoying Tan , Alexander Brodsky , James R. Williamson , Alan D. Frankel
{"title":"HIV-1 Tat和Rev对RNA的识别","authors":"Ruoying Tan , Alexander Brodsky , James R. Williamson , Alan D. Frankel","doi":"10.1006/smvy.1997.0121","DOIUrl":null,"url":null,"abstract":"<div><p>HIV-1 Tat and Rev, two essential regulatory proteins, contain arginine-rich domains that are largely responsible for specific binding to their respective RNA sites, TAR and RRE. Structural studies demonstrate how these RNAs provide precise three-dimensional frameworks for protein binding.<em>In vivo,</em>Tat and Rev interact with additional cellular proteins to carry out their important roles in viral transcription and mRNA processing and transport.</p></div>","PeriodicalId":92955,"journal":{"name":"Seminars in virology","volume":"8 3","pages":"Pages 186-193"},"PeriodicalIF":0.0000,"publicationDate":"1997-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1006/smvy.1997.0121","citationCount":"13","resultStr":"{\"title\":\"RNA Recognition by HIV-1 Tat and Rev\",\"authors\":\"Ruoying Tan , Alexander Brodsky , James R. Williamson , Alan D. Frankel\",\"doi\":\"10.1006/smvy.1997.0121\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>HIV-1 Tat and Rev, two essential regulatory proteins, contain arginine-rich domains that are largely responsible for specific binding to their respective RNA sites, TAR and RRE. Structural studies demonstrate how these RNAs provide precise three-dimensional frameworks for protein binding.<em>In vivo,</em>Tat and Rev interact with additional cellular proteins to carry out their important roles in viral transcription and mRNA processing and transport.</p></div>\",\"PeriodicalId\":92955,\"journal\":{\"name\":\"Seminars in virology\",\"volume\":\"8 3\",\"pages\":\"Pages 186-193\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1997-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1006/smvy.1997.0121\",\"citationCount\":\"13\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Seminars in virology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S1044577397901219\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Seminars in virology","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1044577397901219","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
HIV-1 Tat and Rev, two essential regulatory proteins, contain arginine-rich domains that are largely responsible for specific binding to their respective RNA sites, TAR and RRE. Structural studies demonstrate how these RNAs provide precise three-dimensional frameworks for protein binding.In vivo,Tat and Rev interact with additional cellular proteins to carry out their important roles in viral transcription and mRNA processing and transport.
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