{"title":"N-(3-氨基-4-甲基苯基)苯酰胺的连续合成及其微流系统动力学研究","authors":"Qilin Xu, Guosi Li, Fucheng Zhu, Naidong Chen, Cuiwu Chen, Zhiqun Yu","doi":"10.1007/s41981-022-00241-1","DOIUrl":null,"url":null,"abstract":"<div><p><i>N</i>-(3-Amino-4-methylphenyl)benzamide (<b>1</b>) is a crucial building blocks of many drug candidates. In this paper, a continuous flow microreactor system was developed to synthesize <b>1</b> and determine intrinsic reaction kinetics parameters. By screening the acylating reagents and reaction conditions, <b>1</b> was obtained by the selective acylation of 4-methylbenzene-1,3-diamine (<b>2</b>) with benzoic anhydride (<b>3</b>). Since the two amine groups in <b>2</b> are in different chemical environments, parallel by-products and serial by-products coexist, which makes the selective monoacylation process relatively complicated. To reveal the reaction process clearly, reaction rate constants and their 95% confidence intervals, activation energies, pre-exponential factors were acquired by kinetics study in microflow system. The established kinetic model can calculate the selectivity and conversion of the acylation reaction, which are in good agreement with the experimental results. Subsequently, the kinetic model was used to optimize reaction conditions, as a result, <b>1</b> was synthesized in the microreactor with a yield of 85.7% within 10 min.</p></div>","PeriodicalId":630,"journal":{"name":"Journal of Flow Chemistry","volume":null,"pages":null},"PeriodicalIF":2.0000,"publicationDate":"2022-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s41981-022-00241-1.pdf","citationCount":"0","resultStr":"{\"title\":\"Continuous synthesis of N-(3-Amino-4-methylphenyl)benzamide and its kinetics study in microflow system\",\"authors\":\"Qilin Xu, Guosi Li, Fucheng Zhu, Naidong Chen, Cuiwu Chen, Zhiqun Yu\",\"doi\":\"10.1007/s41981-022-00241-1\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p><i>N</i>-(3-Amino-4-methylphenyl)benzamide (<b>1</b>) is a crucial building blocks of many drug candidates. In this paper, a continuous flow microreactor system was developed to synthesize <b>1</b> and determine intrinsic reaction kinetics parameters. By screening the acylating reagents and reaction conditions, <b>1</b> was obtained by the selective acylation of 4-methylbenzene-1,3-diamine (<b>2</b>) with benzoic anhydride (<b>3</b>). Since the two amine groups in <b>2</b> are in different chemical environments, parallel by-products and serial by-products coexist, which makes the selective monoacylation process relatively complicated. To reveal the reaction process clearly, reaction rate constants and their 95% confidence intervals, activation energies, pre-exponential factors were acquired by kinetics study in microflow system. The established kinetic model can calculate the selectivity and conversion of the acylation reaction, which are in good agreement with the experimental results. Subsequently, the kinetic model was used to optimize reaction conditions, as a result, <b>1</b> was synthesized in the microreactor with a yield of 85.7% within 10 min.</p></div>\",\"PeriodicalId\":630,\"journal\":{\"name\":\"Journal of Flow Chemistry\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":2.0000,\"publicationDate\":\"2022-08-29\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://link.springer.com/content/pdf/10.1007/s41981-022-00241-1.pdf\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Flow Chemistry\",\"FirstCategoryId\":\"92\",\"ListUrlMain\":\"https://link.springer.com/article/10.1007/s41981-022-00241-1\",\"RegionNum\":4,\"RegionCategory\":\"化学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"CHEMISTRY, MULTIDISCIPLINARY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Flow Chemistry","FirstCategoryId":"92","ListUrlMain":"https://link.springer.com/article/10.1007/s41981-022-00241-1","RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"CHEMISTRY, MULTIDISCIPLINARY","Score":null,"Total":0}
Continuous synthesis of N-(3-Amino-4-methylphenyl)benzamide and its kinetics study in microflow system
N-(3-Amino-4-methylphenyl)benzamide (1) is a crucial building blocks of many drug candidates. In this paper, a continuous flow microreactor system was developed to synthesize 1 and determine intrinsic reaction kinetics parameters. By screening the acylating reagents and reaction conditions, 1 was obtained by the selective acylation of 4-methylbenzene-1,3-diamine (2) with benzoic anhydride (3). Since the two amine groups in 2 are in different chemical environments, parallel by-products and serial by-products coexist, which makes the selective monoacylation process relatively complicated. To reveal the reaction process clearly, reaction rate constants and their 95% confidence intervals, activation energies, pre-exponential factors were acquired by kinetics study in microflow system. The established kinetic model can calculate the selectivity and conversion of the acylation reaction, which are in good agreement with the experimental results. Subsequently, the kinetic model was used to optimize reaction conditions, as a result, 1 was synthesized in the microreactor with a yield of 85.7% within 10 min.
期刊介绍:
The main focus of the journal is flow chemistry in inorganic, organic, analytical and process chemistry in the academic research as well as in applied research and development in the pharmaceutical, agrochemical, fine-chemical, petro- chemical, fragrance industry.