继发于大肠弯曲杆菌感染的暴发性格林-巴利综合征：尸检病例报告

Q3 Neuroscience

eNeurologicalSci Pub Date : 2023-06-01 DOI:10.1016/j.ensci.2023.100454

Fumiya Kutsuna , Momoko Soeda , Aiko Hibino , Masahiro Tokuda , Shiro Miura , Hiroshi Iwanaga

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引用次数: 1

摘要

格林-巴利综合征（GBS）之前最常见的感染是空肠弯曲杆菌肠炎，尽管少数患者存在大肠弯曲杆菌。我们报告了一例由大肠杆菌引起的暴发性GBS。一位61岁的女性出现双侧肢体无力。神经传导研究显示振幅降低，从粪便样本中分离出大肠杆菌，从而诊断为GBS。尽管患者立即服用了免疫球蛋白，但她的症状迅速恶化，最终死亡。外周神经解剖显示髓鞘卵球形，CD68阳性巨噬细胞浸润神经。需要开发更有效的治疗暴发性GBS的方法。

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Fulminant Guillain–Barré syndrome secondary to Campylobacter coli infection: An autopsy case report

The most common infection preceding Guillain–Barré syndrome (GBS) is Campylobacter jejuni enteritis, although a few patients present with Campylobacter coli. We report a case of C. coli–induced fulminant GBS. A 61-year-old woman presented with bilateral limb weakness. Nerve conduction studies revealed a reduction of amplitude and C. coli was isolated from a fecal specimen, leading to the diagnosis of GBS. Although the patient was immediately administered immunoglobulin, her symptoms rapidly worsened and she died. Peripheral nerve autopsy revealed myelin ovoid, and infiltration of CD68-positive macrophages into nerves. More effective treatments for fulminant GBS need to be developed.

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来源期刊

eNeurologicalSci Neuroscience-Neurology

CiteScore

3.50

自引率

0.00%

发文量

审稿时长

62 days

期刊介绍： eNeurologicalSci provides a medium for the prompt publication of original articles in neurology and neuroscience from around the world. eNS places special emphasis on articles that: 1) provide guidance to clinicians around the world (Best Practices, Global Neurology); 2) report cutting-edge science related to neurology (Basic and Translational Sciences); 3) educate readers about relevant and practical clinical outcomes in neurology (Outcomes Research); and 4) summarize or editorialize the current state of the literature (Reviews, Commentaries, and Editorials). eNS accepts most types of manuscripts for consideration including original research papers, short communications, reviews, book reviews, letters to the Editor, opinions and editorials. Topics considered will be from neurology-related fields that are of interest to practicing physicians around the world. Examples include neuromuscular diseases, demyelination, atrophies, dementia, neoplasms, infections, epilepsies, disturbances of consciousness, stroke and cerebral circulation, growth and development, plasticity and intermediary metabolism. The fields covered may include neuroanatomy, neurochemistry, neuroendocrinology, neuroepidemiology, neurogenetics, neuroimmunology, neuroophthalmology, neuropathology, neuropharmacology, neurophysiology, neuropsychology, neuroradiology, neurosurgery, neurooncology, neurotoxicology, restorative neurology, and tropical neurology.