Adolfo Gómez-Grande , Alexander P. Seiffert , Alberto Villarejo-Galende , Marta González-Sánchez , Sara Llamas-Velasco , Héctor Bueno , Enrique J. Gómez , María José Tabuenca , Patricia Sánchez-González
{"title":"原发性进行性失语症患者18F标记淀粉样蛋白示踪剂注射后的静态一分钟帧（FMF）PET成像与[18F]FDG PET相关","authors":"Adolfo Gómez-Grande , Alexander P. Seiffert , Alberto Villarejo-Galende , Marta González-Sánchez , Sara Llamas-Velasco , Héctor Bueno , Enrique J. Gómez , María José Tabuenca , Patricia Sánchez-González","doi":"10.1016/j.remnie.2023.02.001","DOIUrl":null,"url":null,"abstract":"<div><h3>Objective</h3><p>To study the correlation between a static PET image of the first-minute-frame (FMF) acquired with <sup>18</sup>F-labeled amyloid-binding radiotracers and brain [<sup>18</sup>F]FDG PET in patients with primary progressive aphasia (PPA).</p></div><div><h3>Material and methods</h3><p>The study cohort includes 17 patients diagnosed with PPA with the following distribution: 9 nonfluent variant PPA, 4 logopenic variant PPA, 1 semantic variant PPA, 3 unclassifiable PPA. Regional SUVRs are extracted from FMFs and their corresponding [<sup>18</sup>F]FDG PET images and Pearson’s correlation coefficients are calculated.</p></div><div><h3>Results</h3><p>SUVRs of both images show similar patterns of regional cerebral alterations. Intrapatient correlation analyses result in a mean coefficient of <em>r</em> <!-->=<!--> <!-->0.94<!--> <!-->±<!--> <!-->0.06. Regional interpatient correlation coefficients of the study cohort are greater than 0.81. Radiotracer-specific and variant-specific subcohorts show no difference in the similarity between the images.</p></div><div><h3>Conclusions</h3><p>The static FMF could be a valid alternative to dynamic early-phase amyloid PET proposed in the literature, and a neurodegeneration biomarker for the diagnosis and classification of PPA in amyloid PET studies.</p></div>","PeriodicalId":94197,"journal":{"name":"Revista espanola de medicina nuclear e imagen molecular","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Static first-minute-frame (FMF) PET imaging after 18F-labeled amyloid tracer injection is correlated to [18F]FDG PET in patients with primary progressive aphasia\",\"authors\":\"Adolfo Gómez-Grande , Alexander P. Seiffert , Alberto Villarejo-Galende , Marta González-Sánchez , Sara Llamas-Velasco , Héctor Bueno , Enrique J. Gómez , María José Tabuenca , Patricia Sánchez-González\",\"doi\":\"10.1016/j.remnie.2023.02.001\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Objective</h3><p>To study the correlation between a static PET image of the first-minute-frame (FMF) acquired with <sup>18</sup>F-labeled amyloid-binding radiotracers and brain [<sup>18</sup>F]FDG PET in patients with primary progressive aphasia (PPA).</p></div><div><h3>Material and methods</h3><p>The study cohort includes 17 patients diagnosed with PPA with the following distribution: 9 nonfluent variant PPA, 4 logopenic variant PPA, 1 semantic variant PPA, 3 unclassifiable PPA. Regional SUVRs are extracted from FMFs and their corresponding [<sup>18</sup>F]FDG PET images and Pearson’s correlation coefficients are calculated.</p></div><div><h3>Results</h3><p>SUVRs of both images show similar patterns of regional cerebral alterations. Intrapatient correlation analyses result in a mean coefficient of <em>r</em> <!-->=<!--> <!-->0.94<!--> <!-->±<!--> <!-->0.06. Regional interpatient correlation coefficients of the study cohort are greater than 0.81. Radiotracer-specific and variant-specific subcohorts show no difference in the similarity between the images.</p></div><div><h3>Conclusions</h3><p>The static FMF could be a valid alternative to dynamic early-phase amyloid PET proposed in the literature, and a neurodegeneration biomarker for the diagnosis and classification of PPA in amyloid PET studies.</p></div>\",\"PeriodicalId\":94197,\"journal\":{\"name\":\"Revista espanola de medicina nuclear e imagen molecular\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2023-07-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Revista espanola de medicina nuclear e imagen molecular\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S2253808923000149\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Revista espanola de medicina nuclear e imagen molecular","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2253808923000149","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Static first-minute-frame (FMF) PET imaging after 18F-labeled amyloid tracer injection is correlated to [18F]FDG PET in patients with primary progressive aphasia
Objective
To study the correlation between a static PET image of the first-minute-frame (FMF) acquired with 18F-labeled amyloid-binding radiotracers and brain [18F]FDG PET in patients with primary progressive aphasia (PPA).
Material and methods
The study cohort includes 17 patients diagnosed with PPA with the following distribution: 9 nonfluent variant PPA, 4 logopenic variant PPA, 1 semantic variant PPA, 3 unclassifiable PPA. Regional SUVRs are extracted from FMFs and their corresponding [18F]FDG PET images and Pearson’s correlation coefficients are calculated.
Results
SUVRs of both images show similar patterns of regional cerebral alterations. Intrapatient correlation analyses result in a mean coefficient of r = 0.94 ± 0.06. Regional interpatient correlation coefficients of the study cohort are greater than 0.81. Radiotracer-specific and variant-specific subcohorts show no difference in the similarity between the images.
Conclusions
The static FMF could be a valid alternative to dynamic early-phase amyloid PET proposed in the literature, and a neurodegeneration biomarker for the diagnosis and classification of PPA in amyloid PET studies.
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