Clinical application of the neonatal early-onset sepsis risk assessment calculator

Neonatal sepsis is divided into early-onset sepsis (EOS) and late-onset sepsis (LOS). The European neonatal detection network reported in 2011 that EOS has a high mortality rate of 26.3%, almost double that of LOS (13.3%). EOS sometimes lacks specific symptoms, which makes early diagnosis difficult and leads to extensive empirical antibiotic therapy with potential hazards and both immediate and long-term adverse outcomes. The Neonatal EOS Risk Calculator is an assessment model proposed in recent years to quantify the risk of EOS in newborns based on a range of high-risk factors in the perinatal period. This model has attracted widespread attention in some developed countries and has been applied in retrospective and prospective clinical studies, suggesting new strategies to address the appropriate use of antibiotics in neonates. This article reviews the clinical application and research progress of the Neonatal EOS Risk Calculator.