Andrea Piccioni , Laura Franza , Federico Rosa , Marcello Candelli , Marcello Covino , Michela Ferrara , Gianpietro Volonnino , Giuseppe Bertozzi , Maria Vittoria Zamponi , Aniello Maiese , Gabriele Savioli , Francesco Franceschi , Raffaele La Russa
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The role of SARS-COV-2 infection in promoting abnormal immune response and sepsis: A comparison between SARS-COV-2-related sepsis and sepsis from other causes
Background
COVID-19 caused by SARS-CoV-2 virus is characterized by respiratory compromise and immune system involvement, even leading to serious disorders, such as cytokine storm.
Methods
We then conducted a literature review on the topic of sepsis and covid-19, and in parallel conducted an experimental study on the histological finding of patients who died from SARS-Covid 19 infection and a control group.
Results
Sepsis associated with covid-19 infection has some similarities and differences from that from other causes.
Conclusion
In this paper the complex interplay between the 2 disorders was discussed, focusing on the similarities and on the effect that one could have on the other. A preliminary experimental section that demonstrates the multisystemic involvement in subjects who die from SARS-CoV-2 is also proposed.
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