靶向肿瘤微环境的纳米光动力疗法

Venkateshwaran Krishnaswami , Balakrishnan Natarajan , Vaidevi Sethuraman , Subramanian Natesan , Brito RajSelvaraj
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引用次数: 1

摘要

最近,光动力疗法(PDT)在治疗癌症微环境中的临床应用大幅增加,这是一种前沿的治疗方法。PDT通过使用氧气、光敏剂和激光来工作。可能的光敏剂的水溶性差和肿瘤抑制微环境降低了PDT的有效性。纳米光动力治疗的优势有助于克服相关挑战。使用双重或三重组合方法,如光热治疗、化疗和放射治疗,可以提高PDT的有效性。本节拟综述的重点是光动力治疗、光敏剂和PDT在医学中的应用。此外,还对基于PDT的癌症治疗进行了展望。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Nano based photodynamic therapy to target tumor microenvironment

Nano based photodynamic therapy to target tumor microenvironment

The cutting-edge therapeutic approach recently has seen a large increase in the clinical application of photodynamic therapy (PDT) in the treatment of cancer microenvironment. PDT works by using oxygen, photosensitizers, and laser light. Poor water solubility of possible photosensitizers and a tumor-suppressive microenvironment have reduced PDT's effectiveness. The advantages of nano-based photodynamic treatment are helping to overcome the relevant challenges. Using a dual or triple combination method, such as photothermal therapy, chemotherapy, and radiation therapy, the effectiveness of PDT can be increased. The proposed review in this section focuses on an overview of photodynamic treatment, photosensitizers, and PDT's applications in medicine. Additionally, a perspective on PDT-based cancer therapy is discussed.

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