Emilia R Gutiérrez-Mireles, José Carlos Páez-Franco, Raúl Rodríguez-Ruíz, Juan Manuel Germán-Acacio, M Casandra López-Aquino, Manuel Gutiérrez-Aguilar
{"title":"缺乏线粒体钙转运调节因子MICU的拟南芥突变体系显示出改变的代谢产物谱。","authors":"Emilia R Gutiérrez-Mireles, José Carlos Páez-Franco, Raúl Rodríguez-Ruíz, Juan Manuel Germán-Acacio, M Casandra López-Aquino, Manuel Gutiérrez-Aguilar","doi":"10.1080/15592324.2023.2271799","DOIUrl":null,"url":null,"abstract":"<p><p>Plant metabolism is constantly changing and requires input signals for efficient regulation. The mitochondrial calcium uniporter (MCU) couples organellar and cytoplasmic calcium oscillations leading to oxidative metabolism regulation in a vast array of species. In <i>Arabidopsis thaliana</i>, genetic deletion of AtMICU leads to altered mitochondrial calcium handling and ultrastructure. Here we aimed to further assess the consequences upon genetic deletion of AtMICU. Our results confirm that AtMICU safeguards intracellular calcium transport associated with carbohydrate, amino acid, and phytol metabolism modifications. The implications of such alterations are discussed.</p>","PeriodicalId":94172,"journal":{"name":"Plant signaling & behavior","volume":"18 1","pages":"2271799"},"PeriodicalIF":0.0000,"publicationDate":"2023-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10601504/pdf/","citationCount":"0","resultStr":"{\"title\":\"An <i>Arabidopsis</i> mutant line lacking the mitochondrial calcium transport regulator MICU shows an altered metabolite profile.\",\"authors\":\"Emilia R Gutiérrez-Mireles, José Carlos Páez-Franco, Raúl Rodríguez-Ruíz, Juan Manuel Germán-Acacio, M Casandra López-Aquino, Manuel Gutiérrez-Aguilar\",\"doi\":\"10.1080/15592324.2023.2271799\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Plant metabolism is constantly changing and requires input signals for efficient regulation. The mitochondrial calcium uniporter (MCU) couples organellar and cytoplasmic calcium oscillations leading to oxidative metabolism regulation in a vast array of species. In <i>Arabidopsis thaliana</i>, genetic deletion of AtMICU leads to altered mitochondrial calcium handling and ultrastructure. Here we aimed to further assess the consequences upon genetic deletion of AtMICU. Our results confirm that AtMICU safeguards intracellular calcium transport associated with carbohydrate, amino acid, and phytol metabolism modifications. The implications of such alterations are discussed.</p>\",\"PeriodicalId\":94172,\"journal\":{\"name\":\"Plant signaling & behavior\",\"volume\":\"18 1\",\"pages\":\"2271799\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2023-12-31\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10601504/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Plant signaling & behavior\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1080/15592324.2023.2271799\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2023/10/25 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Plant signaling & behavior","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1080/15592324.2023.2271799","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2023/10/25 0:00:00","PubModel":"Epub","JCR":"","JCRName":"","Score":null,"Total":0}
An Arabidopsis mutant line lacking the mitochondrial calcium transport regulator MICU shows an altered metabolite profile.
Plant metabolism is constantly changing and requires input signals for efficient regulation. The mitochondrial calcium uniporter (MCU) couples organellar and cytoplasmic calcium oscillations leading to oxidative metabolism regulation in a vast array of species. In Arabidopsis thaliana, genetic deletion of AtMICU leads to altered mitochondrial calcium handling and ultrastructure. Here we aimed to further assess the consequences upon genetic deletion of AtMICU. Our results confirm that AtMICU safeguards intracellular calcium transport associated with carbohydrate, amino acid, and phytol metabolism modifications. The implications of such alterations are discussed.
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