两种未描述的从牡丹中提取的甾体化合物w . Theob。

IF 1.9 3区化学 Q3 CHEMISTRY, APPLIED

Natural Product Research Pub Date : 2025-02-01 DOI:10.1080/14786419.2023.2272286

Wen-Jian Gu , Jin-Qin Ying , Mei-Hua Huang , Miao-Yin Fan , Ya-Mei Zhang

引用次数: 0

摘要

两种未描述的类固醇，命名为（15 R） 2，15-二羟基孕烯-1，4-二烯-3，16-二酮（1）和2，15--二羟基孕二烯-1，4，14-三烯-3，16--二酮（2）是从木犀属植物地上部分分离得到的。采用光谱法和文献比较法对两种化合物进行了结构鉴定。化合物2表现出对PTP-1B的抑制作用，IC50值为152.07 ± 3.33 μM，并且化合物1是无活性的。

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Two undescribed steroids from Munronia pinnata (Wall.) W. Theob

Two undescribed steroids, named (15 R)-2,15-dihydroxypregna-1,4-dien-3,16-dione (1) and 2,15-dihydroxypregna-1,4,14-trien-3,16-dione (2), were isolated from the aerial parts of Munronia pinnata (Wall.) W. Theob. The structure elucidation of two compounds was performed by using spectroscopic methods and comparing the literature. Compound 2 exhibited inhibitory effect against PTP-1B with an IC₅₀ value of 152.07 ± 3.33 μM, and compound 1 was inactive.

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来源期刊

Natural Product Research 化学-医药化学

CiteScore

5.10

自引率

9.10%

发文量

605

审稿时长

2.1 months

期刊介绍： The aim of Natural Product Research is to publish important contributions in the field of natural product chemistry. The journal covers all aspects of research in the chemistry and biochemistry of naturally occurring compounds. The communications include coverage of work on natural substances of land and sea and of plants, microbes and animals. Discussions of structure elucidation, synthesis and experimental biosynthesis of natural products as well as developments of methods in these areas are welcomed in the journal. Finally, research papers in fields on the chemistry-biology boundary, eg. fermentation chemistry, plant tissue culture investigations etc., are accepted into the journal. Natural Product Research issues will be subtitled either ""Part A - Synthesis and Structure"" or ""Part B - Bioactive Natural Products"". for details on this , see the forthcoming articles section. All manuscript submissions are subject to initial appraisal by the Editor, and, if found suitable for further consideration, to peer review by independent, anonymous expert referees. All peer review is single blind and submission is online via ScholarOne Manuscripts.